Analysis of anal human papillomavirus infection among HIV-positive men who have sex with men in Shenzhen
10.3760/cma.j.cn112309-20241028-00365
- VernacularTitle:深圳地区HIV阳性男男性行为人群肛门人乳头瘤病毒感染情况分析
- Author:
Tingdan GONG
1
;
Tianyang LIU
;
Jie QIN
;
Siwei ZHANG
;
Rongqing YANG
;
Wenzhu CHU
;
Lanlan WEI
;
Min ZHUANG
Author Information
1. 哈尔滨医科大学基础医学院微生物教研室，黑龙江省感染与免疫重点实验室，黑龙江省病原生物学重点实验室，哈尔滨 150076
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
Human papillomavirus;
Men who have sex with men;
Genotypes
- From:
Chinese Journal of Microbiology and Immunology
2025;45(4):277-284
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prevalence and genotype distribution of human papillomavirus (HPV) infection in the anorectal region among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) in Shenzhen, and explore the differences between HIV-positive and HIV-negative MSM populations, providing scientific evidence for HPV screening, vaccination, and related disease prevention.Methods:A total of 100 MSM recruited from the Department of Dermatovenerology of the Third People′s Hospital of Shenzhen between 2023 and 2024 were included. Questionnaire collected sociodemographic and clinical characteristics. Anorectal exfoliated cells were analyzed for HPV genotyping, and blood samples were tested for HIV antibodies and T lymphocyte subsets. Chi-square test was used to assess associations between qualitative variables. Results:Among 100 MSM, 58 were HIV-positive and 42 HIV-negative. The overall HPV infection rate was 93.10% (54/58) in HIV-positive MSM, with high-risk HPV at 79.31% (46/58) and low-risk HPV at 75.86% (44/58). The predominant genotypes were HPV6, 11, 16, 52, 18, 59, and 68. In HIV-negative MSM, HPV infection rate was 95.24% (40/42), with high-risk HPV at 57.14% (24/42) and low-risk HPV at 92.50% (37/40), dominated by HPV6, 11, 16, 51 and 52. HIV-positive MSM showed significantly higher infection rates of high-risk HPV16/18 ( P=0.032), HPV58 ( P=0.020), HPV59 ( P=0.031), and HPV68 ( P=0.007) compared to HIV-negative MSM. The maximum number of concurrent HPV infections was 12 in HIV-positive MSM versus 4 in HIV-negative MSM. Multivariate analysis revealed that HIV-positive MSM with CD4/CD8 ratio≤0.9 had significantly higher HPV positivity ( P<0.05). Conclusions:HIV-positive MSM exhibit elevated rates of high-risk and multiple HPV infections, closely associated with immune dysfunction. Strengthened HPV screening, vaccination, and immune status management are critical for preventing HPV-related malignancies in the population.
