Diagnosis and treatment strategies for immune dysfunction in sepsis following severe burns and trauma
10.3760/cma.j.cn501098-20250407-00197
- VernacularTitle:严重烧创伤脓毒症免疫功能障碍的诊疗策略
- Author:
Shuangqing LIU
1
;
Xiaomei ZHU
;
Yongming YAO
Author Information
1. 中国人民解放军总医院第四医学中心急诊医学科，北京 100048
- Publication Type:Journal Article
- Keywords:
Burns;
Sepsis;
Immunity;
Immunophenotyping
- From:
Chinese Journal of Trauma
2025;41(5):433-439
- CountryChina
- Language:Chinese
-
Abstract:
Severe burns and trauma frequently lead to the skin barrier disruption and development of moist burn wound, which can trigger sepsis, septic shock, and even death. Immunodysfunction is closely associated with poor prognosis. In-depth research on the mechanisms of natural and adaptive immune dysfunction can help reveal the essence of the disease. Currently, elucidating the underlying mechanisms of immune dysfunction has become a critical research priority. Such investigations may provide fundamental insights into disease pathogenesis. Besides, accurate immune function assessment holds significant value for early detection of immune dysfunction, judgment of the severity of the condition, precise prediction of the prognosis, and guidance of clinical treatment. Implementing immunomodulatory treatment based on the pathophysiological mechanisms and evaluation results is a necessary approach to restoring the immune function, reducing mortality rate, and improving the prognosis of the patients with sepsis following severe burns and trauma. To this end, the authors systematically examined the characteristics and mechanisms of immune dysfunction, immune assessment as well as classification, and corresponding therapeutics in sepsis following severe burns and trauma, thereby providing a reference for the development of precise diagnosis and treatment strategies for immune dysfunction management.
