Application of hydrogel in postoperative treatment of glioblastoma
10.12354/j.issn.1000-8179.2025.20250905
- VernacularTitle:水凝胶在胶质母细胞瘤术后治疗中的应用
- Author:
Yang SHUDE
1
;
Gao SHUO
;
Liu KAI
;
Feng YUHENG
;
Dong ZHIQIANG
Author Information
1. 兰州大学第二临床医学院(兰州市 730000)
- Publication Type:Journal Article
- Keywords:
hydrogel;
glioblastoma(GBM);
postoperative treatment;
drug delivery system;
biomaterials
- From:
Chinese Journal of Clinical Oncology
2025;52(18):957-962
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma(GBM)is the most aggressive primary malignant tumor in the central nervous system.GBM frequently recurs after surgery and has limited therapeutic options.Hydrogels,characterized by their injectability,biocompatibility,and controlled drug release,of-fer innovative solutions for postoperative GBM management.Advances in hydrogel technology provide new avenues for personalized GBM treatments with significant clinical potential.This article focuses on the current progress in the research on hydrogels as carriers for chemo-therapeutic drugs,immunomodulatory platforms,and multimodal therapeutic systems.Key strategies,including thermo-and pH-responsive gels,co-delivery systems,and the regulation of macrophage function,are analyzed for their therapeutic efficacy.Additionally,the advant-ages of hydrogels in surgical cavity filling,targeted therapy,and recurrence prevention are highlighted.We also discuss the challenges in clin-ical translation and future directions of hydrogel application in postoperative GBM management.
