Hot issues related to sentinel lymph node biopsy for patients with breast cancer
10.12354/j.issn.1000-8179.2025.20250898
- VernacularTitle:乳腺癌前哨淋巴结热点问题浅析
- Author:
Wang XIAOWEN
1
;
Qiu PENGFEI
1
;
Wang YONGSHENG
1
Author Information
1. 山东省肿瘤防治研究院(山东省肿瘤医院)乳腺外科(济南市 250117)
- Publication Type:Journal Article
- Keywords:
breast cancer;
sentinel lymph node;
biopsy;
surgery;
de-escalation radiotherapy
- From:
Chinese Journal of Clinical Oncology
2025;52(18):926-931
- CountryChina
- Language:Chinese
-
Abstract:
Sentinel lymph node biopsy(SLNB)has become the standard technique for axillary staging in breast cancer,promoting a more in-dividualized approach to axillary surgery.This review discusses several current emerging issues in SLNB for patients with breast cancer:inpa-tients with 1-2 positive sentinel lymph nodes(SLNs),studies such as SENOMAC have reinforced the safety of omitting axillary lymph node dissection(ALND),although careful consideration remains necessary for patients with abnormal axillary imaging findings and in the context of post-operative regional nodal radiotherapy strategies.Omission of SLNB may be appropriate in early-stage patients with clinically and ra-diologically negative axilla under strictly defined conditions to further minimize surgical trauma.In parallel,techniques for SLNB after neoad-juvant therapy continue to advance,with tumor safety outcomes becoming increasingly reliable,and the dual de-escalation of both surgery and radiotherapy may be anticipated.In addition,regional lymph nodes serve not only as the initial site of tumor metastasis but also as crit-ical hubs of the adaptive immune response,positioning SLNs a potential window into tumor immune surveillance.
