Research progress in novel gene sequencing technique in prevention and control of hospital-associatal infections
10.11816/cn.ni.2025-250162
- VernacularTitle:新型基因测序技术在医院感染防控中的应用研究进展
- Author:
Hongping TANG
1
;
Meihua YAO
;
Lihua CAO
;
Qingfeng SHI
Author Information
1. 启东市人民医院/南通大学附属启东医院院长室,江苏南通 226299
- Publication Type:Journal Article
- Keywords:
Whole-genome sequencing;
Hospital-associatal infection;
Outbreak of infection;
Molecular tracing;
Met-agenomic next-generation sequencing
- From:
Chinese Journal of Nosocomiology
2025;35(21):3349-3354
- CountryChina
- Language:Chinese
-
Abstract:
The widespread prevalence of multidrug-resistant organisms in clinical settings poses significant challen-ges to the prevention and control of hospital-associatal infections.Novel gene sequencing techniques,such as whole-genome sequencing(WGS)and metagenomic next-generation sequencing(mNGS),have emerged as revo-lutionary tools for precisely tracing to the source of hospital-associatal infection outbreak and the prevention and control through high-resolution genomic analysis.The technical principles and advantages of WGS and mNGS were systematically reviewed in the article.The pivotal roles of the techniques in confirmation of outbreak,identification of infection source,transmission chain rebuilding,study on transmission dynamics and evaluation of effect on in-fection prevention and control were elaborated through analysis of typical cases in China and abroad so as to pro-vide theoretical bases and technical support for precise identification of prevention and control of nosocomial infec-tion.
