Research progress in application of dissolvable microneedles in delivery of vaccine
10.11816/cn.ni.2025-250867
- VernacularTitle:可溶性微针及其在疫苗递送中的应用研究进展
- Author:
Bin WANG
1
;
Dayang ZOU
;
Kehui WANG
;
Xianhuang LI
;
Linhao LI
;
Renhui ZHOU
;
Xingyue DU
;
Wei LIU
Author Information
1. 安徽医科大学公共卫生学院流行病与卫生统计学系,安徽 合肥 230032;解放军疾病预防控制中心免疫规划科,北京 100071
- Publication Type:Journal Article
- Keywords:
Dissolvable microneedle;
Vaccine;
Vaccination method;
Immunogenicity;
Vaccine stability
- From:
Chinese Journal of Nosocomiology
2025;35(21):3344-3348
- CountryChina
- Language:Chinese
-
Abstract:
Dissolvable microneedles(DMNs)offer significant advantages for vaccine delivery,including pain relief,saving drug dose,no contamination of sharp instruments and autonomous operation.The review introduces the materials,fabri-cation processes and physical characteristics of DMNs,focusing on its application in delivering various vaccines,such as influenza vaccines,COVID-19 vaccines,viral hepatitis vaccines and the measles-rubella vaccine.Current research dem-onstrates that DMNs provide significant advantages in enhancing vaccine immunogenicity,boosting vaccine stability and reducing vaccination costs.Yet,challenges confronting the development of DMNs remain in terms of unclear material me-tabolism,skin safety,difficulties in large-scale production and lack of quality standards and regulations.With the continu-ous progress of microneedle technique and constant improvement of policies and regulations,DMNs are expected to play an important role in boosting the convenience of vaccination and raising the coverage rate of vaccination,thereby making significant contributions to human health undertakings.
