Trend analysis of vancomycin resistance of Enterococcus faecalis and Enterococcus faecium in medical institutions of Shanghai and nationwide
10.11816/cn.ni.2025-250915
- VernacularTitle:2014-2023年上海市及全国医疗机构粪肠球菌和屎肠球菌对万古霉素耐药趋势
- Author:
Qi MAO
1
;
Xihong LYU
;
Ping YAN
;
Xifeng LI
;
Liang TIAN
;
Renyi ZHU
;
Song JIANG
Author Information
1. 上海市松江区疾病预防控制中心(上海市松江区卫生健康监督所)寄防消毒科,上海 201620
- Publication Type:Journal Article
- Keywords:
Shanghai;
Medical institution;
Enterococcus faecalis;
Enterococcus faecium;
Vancomycin;
Drug resist-ance trend
- From:
Chinese Journal of Nosocomiology
2025;35(21):3299-3303
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To observe the dynamic change trends of vancomycin resistance rates of Enterococcus fae-calis and Enterococcus faecium in medical institutions of Shanghai and nationwide based on the data from China Antimicrobial Resistance Surveillance System(CARSS)between 2014 and 2023 so as to provide bases for optimi-zing the prevention and control strategies for drug-resistant organisms.METHODS The data regarding to the van-comycin resistance rates of E.faecalis and E.faecium in Shanghai and nationwide were extracted from CARSS.The annual percentage change(APC),average annual percentage change(AAPC)and its 95％confi-dence interval(CI)were calculated by Joinpoint regression model(version 5.4.0).The differences in the changing trends and its statistical significance were analyzed.RESULTS The drug resistance rate of E.faecalis showed a re-markable and continuous decline in Shanghai(AAPC=-85.301％,P＜0.001),the isolation rate of the spe-cies maintained zero after 2019.The drug resistance rate nationwide showed a moderate decreasing amplitude(AAPC=-16.237％,P＜0.001),and there was no significant difference in the changing trend after 2019(P=0.628).The drug resistance rate of E.faecium showed a continuous decline trend in Shanghai(AAPC=-27.838％,P＜0.001),while the drug resistance rate nationwide firstly declined and then rose:with the decline from 2014 to 2020(APC=-18.476％,P＜0.001),the quick rebound from 2020 to 2023(APC=43.976％,P=0.005),and there was no significant difference in the overall change(AAPC=-1.459％,P=0.638).The decreasing amplitudes of drug resistance rates of the two species of Enterococcus were greater in Shanghai than nationwide(all P＜0.001),and the rebounds of drug resistance rates did not emerge nationwide.CONCLUSIONS Shanghai has achieved remarkable effect on control of drug resistance of Enterococcus through the management of antibiotics and infection control measures.The drug resistance rate of E.faecium re-bounds nationwide in recent years,indicating that the prevention and control should be strengthened in grass-roots medical institutions.It is suggested that Shanghai experience should be promoted,and the impact of transmis-sion mechanisms of drug resistance genes and COVID-19 epidemic on the use of antibiotics should be focused on.
