Evaluation of effects of intervention measures to etiological submission rates before antimicrobial therapy based on interrupted time series regression analysis
10.11816/cn.ni.2025-258033
- VernacularTitle:基于中断时间序列回归评价抗菌药物治疗前病原学送检率干预措施的效果
- Author:
Ying WANG
1
;
Meijuan JIN
1
;
Wei DING
1
;
Yao ZHAO
1
;
Xiaochao SONG
1
;
Ruhui HAN
1
Author Information
1. 苏州大学附属第一医院感染管理处,江苏苏州 215006
- Publication Type:Journal Article
- Keywords:
Etiological submission rate;
Antibiotic;
Intervention measure;
Interrupted time series;
Hospital-asso-ciated infection
- From:
Chinese Journal of Nosocomiology
2025;35(21):3320-3325
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the changes of etiological submission rates before the antimicrobial therapy after a series of intervention measures were taken so as to optimize the use and management of antibiotics.METHODS A total of 97,146 patients who were hospitalized and treated with antibiotics in the First Affiliated Hospital of Soochow University from Jul.2021 to Jun.2024 were recruited as the research subjects.Jan.2023 was set as the time node of intervention,the time period from Jul.2021 to Dec.2022 was assigned as the pre-interven-tion group,and the time period from Jan.2023 to Jun.2024 was assigned as the post-intervention group.The etio-logical submission rates before the antimicrobial therapy were observed by interrupted time series before and after the intervention measures were taken.The changes of isolation rates of multidrug-resistant organisms and inci-dence of hospital-associated infections were estimated by chi-square test.RESULTS The etiological submission rates before the antimicrobial therapy,etiological submission rates before combined use of major antibiotics and etiological submission rates relating to diagnosis of hospital-associated infections were higher after the intervention than before the intervention(all P＜0.05).The interrupted time series analysis showed that from the perspective of long-term benefit,the intervention measures could raise the etiological submission rates before the use of re-stricted,special grades of antibiotics and general antibiotics,and the net benefits were 0.85％,0.67％and 0.68％,respectively(all P＜0.05);there was no significant difference in the etiological submission rate before the com-bined use of major antibiotics.After the intervention,the incidence of multidrug-resistant organisms infection de-creased from 0.46％to 0.27％(P＜0.001);the isolation rate of multidrug-resistant organisms was 25.73％after the intervention,27.47％before the intervention,and there was no significant difference.CONCLUSIONS Scientif-ic and reasonable interventions may effectively raise the etiological submission rates before the antimicrobial thera-py,however,the etiological submission rate for combined use of major antibiotics and the isolation rate of multi-drug-resistant organisms are not improved remarkably.It is necessary to further formulate targeted interven-tion measures so as to push forward high-quality development of infection control.
