Use of carbapenems and β-lactamase inhibitors in a hospital before and after specialized management and control of antibiotics and its economic evaluation
10.11816/cn.ni.2025-258101
- VernacularTitle:某院碳青霉烯类与β-内酰胺酶抑制剂在抗菌药物专项管控前后的使用情况及经济学评价
- Author:
Jin QIAO
1
;
Yan ZHAO
;
Fang WANG
Author Information
1. 南通市第三人民医院/南通大学附属南通第三医院药学部,江苏南通 226006
- Publication Type:Journal Article
- Keywords:
Carbapenem;
β-lactamases inhibitor;
Tertiary hospital;
Antibiotic specialized management and control;
Economic evaluation
- From:
Chinese Journal of Nosocomiology
2025;35(21):3206-3210
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the use of carbapenems and β-lactamase inhibitors in a hospital before and after specialized management and control of antibiotics and carry out economic evaluation.METHODS The patients who were hospitalized and treated with amoxicillin-clavulanate potassium,piperacillin-tazobactam,cefoperazone-sul-bactam and meropenem in Nantong Third Hospital Affiliated to Nantong University from Jul.2021 to Dec.2021(before the specialized management and control,5086 cases)and from Jul.2022 to Dec.2022(after the special-ized management and control,2040 cases)were recruited as the research subjects.The utilization rates of antibiot-ics,antimicrobial use density(AUD),rates of prophylactic use of type Ⅰ incision antibiotics,drug utilization in-dexes(DUIs),rates of rational advice,constituent ratios of antibiotics,minimum cost analysis of prophylactic an-tibiotics and costs of antimicrobial treatments were observed and compared before and after the specialized man-agement and control.RESULTS The utilization rates of amoxicillin-clavulanate potassium,piperacillin-tazobactam and cefoperazone-sulbactam were decreased from 5.23％,11.70％and 3.30％before the specialized management and control to 3.01％,3.56％and 1.62％after the specialized management and control(all P＜0.05),and the AUDs were decreased by 1.48,40.15 and 3.22,respectively.The DUIs of the four types of antibiotics were closer to 1 after the specialized management and control than before the specialized management and control.The rates of rational advice for amoxicillin-clavulanate potassium,piperacillin-tazobactam and cefoperazone-sulbactam were higher after the specialized management and control than before the specialized management and control(allP＜0.05).The prophylactic use of β-lactamase inhibitors and carbapenems antibiotics for type Ⅰ incision was strictly under control;the costs of treatment of type Ⅰ,Ⅱ incisions were better(all P＜0.05)and the total costs of two categories of drugs for type Ⅰ,Ⅱ incisions were lower after the specialized management and control than before the specialized management and control(P＜0.05).CONCLUSION The precise specialized management and con-trol has achieved initial effect on carbapenems and β-lactamases inhibitors,which improves the rationality of clini-cal use of drugs and cuts the costs,and the efficacy of the management and control needs to be further improved and optimized.
