Therapeutic effect assessment of hyperbaric oxygen in treating diabetic kidney disease by color Doppler ultrasonography
10.3760/cma.j.cn311847-20210224-00066
- VernacularTitle:彩色多普勒超声技术评价高压氧辅助治疗糖尿病肾病疗效的研究
- Author:
Liang ZHANG
1
;
Yan WANG
;
Jin’e WAN
;
Ruixia MA
;
Xue YANG
;
Ning YU
Author Information
1. 266000 山东省青岛，青岛大学附属医院腹部超声科
- Publication Type:Journal Article
- Keywords:
Color Doppler;
Hyperbaric oxygen;
Diabetic kidney disease
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2021;28(6):784-787
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the assessment value of color Doppler ultrasonography on patients with diabetic kidney disease (DKD) treated by hyperbaric oxygen (HBO) therapy.Methods:A total of 64 DKD patients confirmed in the Affiliated Hospital of Qingdao University from October 2019 to October 2020 were divided into control group ( n=32) and HBO group ( n=32) using the random number table. The control group was given comprehensive treatments (conventional hypoglycemic and antihypertensive treatment, low-fat, low-salt, and low-sugar diet, and physical exercise), and the HBO group was given HBO based on the treatment in the control group. Color Doppler ultrasound examination was performed on each patient before and after treatment, and renal hemodynamic indicators such as peak systolic velocity (PSV), end diastolic velocity (EDV), resistance index (RI), and pulsatility index (PI) were recorded. After treatment, receiver operating characteristic (ROC) curves related to therapeutic effect were made based on the indicators of RI, PI, EDV, and PSV. Results:After treatment, the 24-hour urinary albumin excretion rate (UAER), blood urea nitrogen (BUN), EDV, PSV, RI, and PI in the control group and the HBO group were all improved compared with those before treatment, and all the above indicators in HBO group had greater improvement than those in the control group, with a statistically significant differences ( P<0.05). After treatment, the total effective rate of the HBO group (96.88%) was higher than that of the control group (75.01%), with a statistically significant difference ( P<0.05). According to the calculation, RI, PI, and EDV had some value for evaluating the efficacy of HBO on DKD patients, specifically, when the area under ROC of RI was 0.866, the cutoff value was 0.76, the sensitivity was 72.73%, and the specificity was 91.38%. Conclusion:The comprehensive treatments combined with HBO have a good effect on DKD. With the non-invasive and real-time advantages, color Doppler ultrasound can be adopted to monitor RI for assessing the efficacy of DKD treatment. When the RI cutoff value reaches 0.76, it has some value for evaluating the curative effect of DKD treatment.
