Investigating Causal Relationships Between Serum Trace Elements and Head and Neck Cancers:a Two-Sample Bidirectional Mendelian Randomization Study
10.11735/j.issn.1004-0242.2025.11.A010
- VernacularTitle:微量元素与头颈部肿瘤的因果关联研究:一项两样本双向孟德尔随机化分析
- Author:
Jiayu SONG
1
;
Yanning LI
;
Lina LIU
;
Qianyong HE
;
Kai SHANG
;
Yue CHEN
;
Xunyan LUO
;
Zhuoling LI
;
Xiaomei LI
;
Feng JIN
Author Information
1. 贵州医科大学附属医院,贵州贵阳 550004;贵州医科大学附属肿瘤医院,贵州贵阳 550004;贵州医科大学临床医学院,贵州贵阳 550004
- Publication Type:Journal Article
- Keywords:
trace elements;
oral cavity cancer;
laryngeal cancer;
oropharyngeal cancer;
thyroid cancer;
Mendelian randomization
- From:
China Cancer
2025;34(11):898-910
- CountryChina
- Language:Chinese
-
Abstract:
[Purpose]To investigate the potential causal relationships between serum levels of trace elements and head and neck cancers.[Methods]Single nucleotide polymorphism(SNP)of oral cancer,oropharyngeal cancer,laryngeal cancer and thyroid cancer,associated with calcium,copper,iron,magnesium,zinc,were obtained from genome-wide association studies(GWAS).A two-sample bidirectional Mendelian randomization(MR)analysis was performed using the inverse variance weighting(IVW)method by calculating odds ratio(OR)and 95％confidence interval(CI).Pleiotropy was assessed using MR-PRESSO and MR-Egger regression,and sensitivity analysis was conducted via the"leave-one-out"method.[Results]IVW analysis revealed a causal association between serum magnesium levels and the incidence of oral cancer(OR=0.976,95％CI:0.956～0.997,P=0.025),also between thyroid cancer and serum calcium levels(OR=1.008,95％CI:1.001～1.015,P=0.023).No significant causal associations were observed between other trace ele-ments and head and neck cancers(all P＞0.05).[Conclusion]This MR study suggests that serum magnesium levels serve as a protective factor against oral cancer,while thyroid cancer leads to el-evated serum calcium levels.
