Efficacy analysis of doxycycline in the treatment of Mycoplasmal pneumoniae pneumonia in children under 8 years old
10.3969/j.issn.1673-9701.2025.31.011
- VernacularTitle:多西环素治疗8岁以下儿童肺炎支原体肺炎的疗效分析
- Author:
Haitao LYU
1
;
Tengteng SHEN
1
;
Huiqing XU
1
;
Yuebo XU
1
;
Jishan ZHENG
1
Author Information
1. 宁波大学附属妇女儿童医院儿科,浙江宁波 315000
- Publication Type:Journal Article
- Keywords:
Doxycycline;
Mycoplasmal pneumoniae pneumonia;
Off-label drug use;
Clinical efficacy
- From:
China Modern Doctor
2025;63(31):54-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of doxycycline in the treatment of Mycoplasmal pneumoniae pneumonia(MPP)in children under 8 years old.Methods A retrospective selection was made of 258 children with MPP under 8 years old who were admitted to Women and Children's Hospital of Ningbo University from July 2023 to June 2024 as the research subjects.The children were divided into the azithromycin group(n=156)and the doxycycline group(n=102)according to the different drugs used.The clinical indicators,inflammation-related indicators,liver function indicators before and after treatment and adverse reactions of two groups of children were compared.Results After treatment,the defervescence time,cough relief time,pneumonia image absorption time and hospital stay in doxycycline group were shorter than those in azithromycin group(P＜0.05),the number of patients who needed to use steroids and bronchoscope intervention,and the number of patients with total hospitalization costs more than 10 000 yuan were less than those in azithromycin group(P＜0.05).The C-reactive protein(CRP),D-dimer(DD),serum ferritin(SF)and lactate dehydrogenase(LDH)in both groups of children were significantly lower than those before treatment in this group(P＜0.05),and the reduction amplitzes of CRP,DD,SF and LDH in doxycycline group were significantly greater than those in azithromycin group(P＜0.05).There were no significant changes in alanine aminotransferase,aspartate aminotransferase and prealbumin between two groups of children before and after treatment(P＞0.05).The adverse reactions of two groups of children were mainly gastrointestinal reactions,and there was no statistically significant difference in the incidence rate(x2=0.254,P=0.204).Conclusion Doxycycline in treatment of MPP in children under 8 years old can effectively relieve clinical symptoms,reduce inflammatory responses,decrease hormone and bronchoscopy interventions,shorten hospital stays and reduce hospitalization costs,and has good safety.
