Meta-analysis of Chaihu Shugan powder combined with western medicine in the treatment of post-stroke depression
10.3969/j.issn.1673-9701.2025.31.008
- VernacularTitle:柴胡疏肝散联合西药治疗卒中后抑郁的Meta分析
- Author:
Xian LIU
1
;
Rou SHEN
;
Hujun GUO
Author Information
1. 贵州中医药大学第一临床医学院,贵州贵阳 550025
- Publication Type:Journal Article
- Keywords:
Chaihu Shugan powder;
Western medicine;
Post-stroke depression;
Meta-analysis
- From:
China Modern Doctor
2025;63(31):36-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically evaluate the efficacy of Chaihu Shugan powder combined with western medicine in the treatment of post-stroke depression(PSD),so as to provide a reference for clinical practice.Methods Randomized controlled trials on Chaihu Shugan powder combined with western medicine in the treatment of PSD were retrieved from CNKI,VIP,Wanfang Data Knowledge Service Platform,SinoMed and PubMed.The quality of the included literatures was evaluated using the Cochrane handbook,and data analysis was performed with RevMan 5.3 software.Results A total of 26 literatures involving 2287 patients were included.Meta-analysis showed that there were significant statistical differences between combined group and control group in terms of total effective rates(RR=1.22,95％CI:1.17-1.26,Z=9.82,P＜0.000 01),Hamilton depression scale score(SMD=-1.66,95％CI:-2.94--2.22,Z=9.17,P＜0.000 01),National Institutes of Health stroke scale score(MD=-1.59,95％CI:-2.14--1.04,Z=5.64,P＜0.000 01),5-hydroxytryptamine level(MD=14.95,95％CI:10.07-19.83,Z=6.01,P＜0.000 01)and adverse reactions(RR=0.49,95％CI:0.36-0.66,Z=4.64,P＜0.000 01).Conclusion Compared with the treatment with western medicine alone,the combination of Chaihu Shugan powder and western medicine in the treatment of PSD has good efficacy and safety.However,given the low quality of the included literature,higher-quality randomized controlled trials are needed for verification in the future.
