Effects of different cardiac resynchronization therapies on electrocardiogram,left ventricular function and adverse events in elderly patients with heart failure
10.3969/j.issn.1009-0126.2025.11.013
- VernacularTitle:不同心脏再同步治疗对老年心力衰竭患者心电图与左心室功能及不良事件影响的比较
- Author:
Rui MU
1
;
Huiyang GAO
1
;
Guoyu JIN
1
;
Qian LIU
1
;
Xiaofeng SHANG
1
Author Information
1. 甘肃省白银市第二人民医院心内科,甘肃白银 730900
- Publication Type:Journal Article
- Keywords:
heart failure;
cardiac resynchronization therapy;
bundle of His;
left bundle branch pacing
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(11):1502-1506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of cardiac resynchronization therapy at different pacing sites on electrocardiogram(ECG),left ventricular(LV)function and adverse events in elderly patients with heart failure(HF).Methods A total of 214 elderly HF patients admitted to our department between July 2021 and July 2024 were retrospectively recruited.According to different pacing sites in cardiac resynchronization therapy,they were divided into His bundle group(102 cases)and left bundle branch group(112 cases).Their grades of New York Heart Association(NYHA)cardiac function,duration of QRS complex,pacing parameters(pacing threshold,pacing perception,pacing resistance),cardiac function indicators,LV function,LV systolic synchrony[standard deviation of time to peak longitudinal strain,to peak radial strain and to peak circumferential strain(Tls-SD,Trs-SD and Tcs-SD)],and incidence of adverse events were compared between the two groups before and at 6 months after cardiac pacemaker implantation.Results In 6 months after surgery the left bundle branch group had significantly lower N-terminal pro-B-type natriuretic peptide level,smaller LV end-diastolic diameter and LV end-systolic diameter,decreased Tls-SD,Trs-SD and Tcs-SD,and shorter duration of QRS complex,but higher LV ejection fraction,cardiac index and cardiac output when compared with the His bundle group(P＜0.01).The incidence of adverse events was obviously lower in the left bundle branch group than the His bundle group(6.25％vs 15.69％,P＜0.05).Conclusion Left bundle branch pacing shows significant improvement for cardiac function in elderly HF patients,and can effectively maintain ECG stability and improve LV function.It is a safe and effective cardiac resynchronization therapy.
