Orthostatic hypotension-related serum biomarkers in patients with multiple system atrophy
10.3969/j.issn.1009-0126.2025.11.022
- VernacularTitle:多系统萎缩患者直立性低血压相关血清标志物分析
- Author:
Jilin CHEN
1
;
Hairong QIAN
1
;
Xiaohui YANG
1
;
Qianyao WANG
1
;
Na REN
1
;
Min LI
1
;
Hua LI
1
Author Information
1. 解放军总医院第三医学中心神经内科,北京 100039
- Publication Type:Journal Article
- Keywords:
Vitamin D;
uric acid;
cholesterol,LDL;
multiple system atrophy;
hypotension,orthostatic
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(11):1543-1546
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the related influencing factors of orthostatic hypotension in patients with multiple system atrophy(MSA).Methods A retrospective study was conducted on 40 elderly MSA patients with orthostatic hypotension(MSA group)admitted to our department from January 2024 to March 2025,and another 46 elderly healthy individuals without orthostatic hypotension who taking physical examination were subjected and served as control group.General clinical data and related clinical indicators were compared between the two groups,and the related serum biomarkers of orthostatic hypotension in MSA patients were analyzed.Results The levels of vitamin D,low-density lipoprotein cholesterol(LDL-C),and uric acid were significantly lower in the MSA group than the control group(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that vitamin D,LDL-C,and uric acid levels were risk factors for the occurrence of orthostatic hypotension in MSA patients(OR=0.677,95％CI:0.530-0.864,P＜0.01;OR=0.057,95％CI:0.007-0.434,P＜0.01;OR=0.972,95％CI:0.954-0.992,P＜0.01).ROC curve analysis indicated that the optimal cut-off value of vitamin D,LDL-C,and uric acid levels in predicting the occurrence of orthostatic hypotension in MSA patients was 21.850 μg/L,2.895 mmol/L,and 274.500 μmol/L,the sensitivity was 0.848,0.630 and 0.783,and the specificity was 0.792,0.750 and 0.667,and the AUC value was 0.862,0.683 and 0.748,respectively.Conclusion Monitoring serum biomarkers,such as vitamin D,LDL-C,and uric acid may be helpful for the risk assessment and management of orthostatic hypotension in MSA patients.
