Double-Flower Moisturizing Ointment with Occlusive Dressing Therapy Managing Vascular Endothelial Growth Factor Receptor-Tyrosine Kinase Inhibitors Induced Hand-Foot Skin Reaction
10.16466/j.issn1005-5509.2025.10.016
- VernacularTitle:双花滋润膏封包疗法治疗血管内皮生长因子受体酪氨酸激酶抑制剂相关手足皮肤反应
- Author:
Lingxia JIANG
1
;
Zhendong LIU
1
Author Information
1. 浙江中医药大学附属第一医院(浙江省中医院)杭州 310006
- Publication Type:Journal Article
- Keywords:
tyrosine kinase inhibitors;
hand-foot skin reaction;
tumor;
Double-Flower Moisturizing Ointment;
occlusive dressing therapy;
pain;
quality of life;
traditional Chinese medicine syndrome differentiation
- From:
Journal of Zhejiang Chinese Medical University
2025;49(10):1316-1320
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the efficacy and safety of Double-Flower Moisturizing Ointment occlusive dressing therapy in treating vascular endothelial growth factor receptor-tyrosine kinase inhibitors(VEGFR-TKIs)induced hand-foot skin reactions(HFSR).[Methods]A total of 58 cancer patients with HFSR induced by VEGFR-TKIs,who were treated at The First Affiliated Hospital of Zhejiang Chinese Medical University from October 8,2021 to December 31,2024,were enrolled in this study.Using a randomized single-blind design,they were assigned to either an observation group(29 cases)or a control group(29 cases).The observation group received oral vitamin B6 combined with Double-Flower Moisturizing Ointment occlusive dressing therapy,while the control group received oral vitamin B6 combined with base ointment occlusive therapy.Both groups were treated for 14 consecutive days.The total effective rate of HFSR management,pain relief rate,quality of life improvement,differences in efficacy between syndrome types and the incidence of adverse reactions were compared between the two groups.[Results]The total effective rate was significantly higher in observation group(89.7%)than in control group(58.6%).The observation group demonstrated a markedly superior overall pain relief rate of 76.9%,which was significantly higher than the 38.5%achieved in control group.Similarly,the quality of life improvement rate in observation group(44.8%)was markedly higher than that in control group(13.8%),with all differences being statistically significant(P<0.05).In the two main syndrome types of damp-heat stagnation and heat-toxicity accumulation on the skin,the observation group exhibited a significantly greater total effective rate compared to control group(P<0.05).No cutaneous adverse reactions or abnormal liver and kidney function were observed in either group.[Conclusion]Double-Flower Moisturizing Ointment occlusive therapy is effective in managing VEGFR-TKIs-induced HFSR.It demonstrates superior outcomes over base ointment occlusive dressing therapy in terms of the overall response rate,pain relief and quality of life improvement,particularly among patients presenting with damp-heat stagnation or heat-toxicity accumulation on the skin.Furthermore,this treatment modality exhibits a favorable safety profile,indicating high clinical application value.
