Impact of new-onset atrial fibrillation on all-cause mortality in elderly patients with hypertension
10.3969/j.issn.1009-0126.2025.11.007
- VernacularTitle:老年高血压患者新发心房颤动对全因死亡的影响
- Author:
Guohong TU
1
;
Yabin WANG
;
Xiaochun LU
;
Na GAO
;
Xiaoqian LI
;
Haijun WANG
Author Information
1. 解放军总医院第二医学中心心血管内科 国家老年疾病临床医学研究中心,北京 100853
- Publication Type:Journal Article
- Keywords:
hypertension;
atrial fibrillation;
risk factor;
all-cause mortality
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(11):1475-1478
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of new-onset atrial fibrillation(AF)on all-cause mortality in elderly patients with hypertension having no previous history of AF.Methods A retrospective study was conducted on 1352 elderly hypertensive inpatients who had no history of AF and received long-term follow-up in Chinese PLA General Hospital from January 2014 to June 2017.According to having newly developed AF or not,they were divided into a new-set AF group(191 cases)and a control group(1161 cases).Kaplan-Meier survival curve was plotted for survival analysis and multivariate Cox survival analysis was performed to identify risk factors for all-cause mortality.Results Compared with the control group,the new-onset AF group exhibited significantly advanced age,higher urea level,lower diabetes ratio,and decreased hemoglobin level(P＜0.05,P＜0.01).Kaplan-Meier survival curve analysis showed that the cumulative mortality of the new-onset AF group was significantly higher than that of the control group(P＜0.01).Multivariate Cox regression analysis revealed that age＞75 years(HR=4.562,95％CI:3.104-6.705,P＜0.01),anemia(HR=2.543,95％CI:1.939-3.334,P＜0.01),new-onset AF(HR=1.494,95％CI:1.185-1.884,P＜0.01),eGFR＜60 mL/(min·1.73 m2)(HR=1.729,95％CI:1.389-2.151,P＜0.01),and heart failure(HR=1.539,95％CI:1.173-2.019,P＜0.01)were risk factors for all-cause mortality in elderly hypertensive patients without a history of AF.Conclusions New-onset AF is closely associated with an increased risk of all-cause mortality in elderly hypertensive patients without a previous history of AF.
