Research progress on the mechanism and diagnosis and treatment of acute liver failure in heat stroke
10.3969/j.issn.1008-9691.2025.04.023
- VernacularTitle:热射病急性肝衰竭的发生机制和诊疗研究进展
- Author:
Jiaxing WANG
1
;
Linyu CHANG
1
;
Yuxiang ZHANG
1
Author Information
1. 解放军总医院第八医学中心重症医学科,北京 100091
- Publication Type:Journal Article
- Keywords:
Heat stroke;
Liver injury;
Liver failure;
Occurrence mechanism;
Clinical evaluation and diagnosis;
Treatment
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2025;32(4):508-512
- CountryChina
- Language:Chinese
-
Abstract:
Heat stroke is a life-threatening emergency characterized by a rapid elevation in core body temperature(typically>40℃)and central nervous system dysfunction(e.g.,delirium,seizures or coma),often accompanied by systemic inflammatory response,coagulation disorders,and multiple organ failure,with an extremely high mortality rate.Among the multiple organ injuries caused by heat stroke,the liver,as the core organ for metabolism and detoxification in the body,is one of the targets that are vulnerable to high temperatures.If not intervened promptly and effectively,acute liver injury(ALI)can rapidly evolve into acute liver failure(ALF),significantly increasing the complexity of clinical treatment and the risk of patient death.In recent years,with the frequent occurrence of heat wave events worldwide,the pathological mechanisms and prevention strategies of heat stroke and its related liver injuries have received increasingly widespread attention.Although basic and clinical studies have made certain progress,revealing key pathological changes such as hepatocyte necrosis,excessive inflammatory response and coagulopathy,there is still a lack of unified and standardized consensus guidelines for the clinical evaluation,diagnosis and systematic treatment of heat stroke combined with liver failure.Therefore,this article aims to systematically review and summarize the pathogenesis,clinical presentation,diagnostic approaches,and treatment strategies of current liver failure related to heat stroke,in order to provide clear diagnostic and treatment ideas and practical references for clinical workers,and thereby provide theoretical basis and clinical guidance for improving the prognosis of critically ill patients with heat stroke liver failure.
