Two-sample Mendelian randomization study of the causal relationship between asthma-related pneumonia and heart failure
10.3969/j.issn.1673-9701.2025.32.006
- VernacularTitle:哮喘相关性肺炎与心力衰竭因果关系的双向两样本孟德尔随机化研究
- Author:
Zhaohai SU
1
;
Jun CAO
;
Shirong WU
;
Rongyuan YANG
;
Qing LIU
;
Qingyan LIU
Author Information
1. 广东省人民医院赣州医院(赣州市立医院)心血管内科,江西赣州 341000
- Publication Type:Journal Article
- Keywords:
Asthma-related pneumonia;
Heart failure;
Mendelian randomization analysis;
Causal relationship
- From:
China Modern Doctor
2025;63(32):22-27
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To explore the causal relationship between asthma-related pneumonia and heart failure(HF)by using two-sample Mendelian randomization(MR)analysis.Methods The causal relationship between asthma-related pneumonia and HF were systematically evaluated through two-sample MR analysis based on publicly available Genome-Wide Association Study data.Inverse variance weighted(IVW),MR-Egger,weighted median,weighted mode,and simple mode methods were used.Different models were used to analyze sensitivity.Testing approaches were conducted to assess the robustness of the results.Results IVW analysis results showed that there was a causal relationship between asthma-related pneumonia and HF risk(OR=1.113,95％CI:1.027-1.206,P=0.009).HF was not found to have a causal effect on asthma-related pneumonia risk based on IVW analysis(OR=1.018,95％CI:0.780-1.328,P=0.893).The variance used in all MR analyses showed no heterogeneity or horizontal pleiotropy.The leave-one-out analysis revealed that no single nucleotide polymorphism disproportionately influenced the results,further confirming the credibility of the bidirectional MR findings.Conclusion This study established a causal relationship between asthma-related pneumonia and HF risk.No clear causal relationship between HF and asthma-related pneumonia risk was found.
