Discussion on the Synergy Effect of"Wine Decoction"Based on Zhigancao Decoction
10.16466/j.issn1005-5509.2025.07.010
- VernacularTitle:基于炙甘草汤浅议"酒煎服"的增效作用
- Author:
Zhaoyang WU
1
;
Rongqun LI
Author Information
1. 浙江中医药大学附属第一医院 杭州 310006
- Publication Type:Journal Article
- Keywords:
wine;
Zhigancao Decoction;
wine decoction;
arrhythmia;
clinical application;
traditional Chinese medicine;
basic research;
synergy effect
- From:
Journal of Zhejiang Chinese Medical University
2025;49(7):862-865
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To explore the mechanism of clear wine and analyze the theoretical and practical significance of co-decoction of wine and water recorded in Treatise on Febrile Diseases such as Zhigancao Decoction.[Methods]Grounded in the decoction methodologies documented in ancient texts such as Treatise on Febrile Diseases and the"wine-mediated drug delivery"theory,integrating modern pharmacological investigations with quantitative analysis of bioactive component dissolution,and conducting comparative clinical efficacy assessments through contemporary case studies,the synergy effect of clear wine in Zhigancao Decoction was systematically elucidated.[Results]Ancient texts emphasized the role of clear wine in Zhigancao Decoction for promoting blood circulation and drug efficacy,yet many later derivative formulas abandoned wine decoction,suggesting its synergy effects may vary with herbal compatibility and pathogenic mechanisms.Modern studies confirmed that clear wine enhances partial efficacy by increasing the dissolution of lipophilic components(such as catalpol and 5-hydroxymethylfurfural),but the regulation of herbal compatibility and decoction techniques played a more critical role in therapeutic outcomes.Clinical data demonstrated similar efficacy of water-decocted groups in relieving primary symptoms such as arrhythmia compared with clear wine-decocted groups,with no advantage observed across wine types,supporting the notion that the solvent-mediated synergy effect of clear wine in Zhigancao Decoction was non-essential.[Conclusion]Effect of promoting blood circulation and drug efficacy by clear wine exhibits pathomechanism specificity.In Zhigancao Decoction,its therapeutic action is constrained by herbal compatibility and decoction techniques,demonstrating no significant therapeutic effect on the formula's principal indications.Further multicenter randomized controlled trials can be conducted to verify the efficacy of clear wine.
