Preoperative peripheral blood CRP,total protein and tumor markers in predicting postoperative abdominal infection in cholangiocarcinoma
10.11816/cn.ni.2025-251118
- VernacularTitle:术前外周血CRP和总蛋白联合肿瘤标志物对胆管癌术后腹腔感染的预测价值
- Author:
Xinghe HU
1
;
Zhe LIU
;
Shichun LU
;
Xinjiang WANG
Author Information
1. 解放军总医院第二医学中心放射诊断科,北京 100853
- Publication Type:Journal Article
- Keywords:
Perihilar cholangiocarcinoma;
Cholangiocarcinoma;
Abdominal cavity infection;
Predictive factor;
Radical resection
- From:
Chinese Journal of Nosocomiology
2025;35(16):2471-2475
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the value of preoperative serum laboratory indicators in the diagnosis of postop-erative abdominal infection in patients with perihilar cholangiocarcinoma.METHODS We retrospectively collected 444 patients who underwent radical resection of perihilar cholangiocarcinoma at the First Medical Center of the People's Liberation Army General Hospital from Jan.2021 to Apr.2023.According to whether postoperative ab-dominal cavity infection occurred,patients were divided into an infection group(52 cases)and a no-infection group(392 cases).The general clinical data,intraoperative and postoperative conditions of the two patient groups were compared.Multivariate logistic regression analysis was employed to investigate the predictive value of preoperative laboratory indicators in the diagnosis of postoperative abdominal infections.RESULTS The abdominal cavity infec-tion rate was 11.71％in patients undergoing radical resection of perihilar cholangiocarcinoma.Compared with the non-infection group,the infection group had significantly higher intraoperative red blood cell transfusion vol-umes,higher incidence rates of postoperative biliary fistula and a longer postoperative hospital stay(P＜0.05).Preoperative serum total protein,C-reactive protein(CRP),carcinoembryonic antigen(CEA),carbohy-drate antigen(CA)125,CA15-3,and CA72-4 were independent risk factors in predicting postoperative abdominal cavity infection in patients with perihilar cholangiocarcinoma(P＜0.05).The receiver operating characteristic(ROC)analysis results showed that the area under the curve(AUC)value of the combination of these six indica-tors for diagnosing postoperative abdominal cavity infection in perihilar cholangiocarcinoma was 0.873(95％CI:0.818-0.929),with a sensitivity of 73.1％(95％CI:0.590-0.844)and a specificity of 87.0％(95％CI:0.833-0.902).CONCLUSION Preoperative peripheral blood CRP,total protein and tumor markers of patients with peri-hilar cholangiocarcinoma have high diagnostic values for postoperative abdominal cavity infection.
