Research Progress of Chinese Materia Medica Regulating TGF-β Signaling Pathway in Intervention of Chronic Heart Failure
10.19879/j.cnki.1005-5304.202410241
- VernacularTitle:中药调控TGF-β信号通路干预慢性心力衰竭研究进展
- Author:
Kun LIAN
1
;
Yichang XU
1
;
Ying DENG
1
;
Peiyao LI
1
;
Weijun LI
1
;
Lin LI
1
;
Zhixi HU
1
Author Information
1. 湖南中医药大学,湖南 长沙 410208
- Publication Type:Journal Article
- Keywords:
chronic heart failure;
TGF-β signaling pathway;
myocardial fibrosis;
apoptosis;
inflammatory response;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(9):192-197
- CountryChina
- Language:Chinese
-
Abstract:
Chronic heart failure(CHF)is the end-stage of a variety of heart diseases with complex pathogenesis,which may involve myocardial fibrosis,inflammation reaction and oxidative stress.Chinese materia medica has the characteristics of multiple pathways,levels,and targets in the treatment of CHF,with significant therapeutic effects.Based on the TCM theories,this article described the research progress of TCM and its effective components,TCM compounds and Chinese patent medicines in regulating TGF-β signaling pathway in the treatment of CHF,and summarized the mechanism and target of TCM regulating TGF-β pathway in the treatment of CHF,including inhibiting myocardial fibrosis,reducing inflammatory reaction and apoptosis,so as to provide a reference for the related research of Chinese materia medica in the treatment of CHF.
