Research Progress in Mechanism of Chinese Materia Medica in the Prevention and Treatment of Knee Osteoarthritis and Osteoporosis Co-morbidity Based on Exosomes
10.19879/j.cnki.1005-5304.202410070
- VernacularTitle:中药基于外泌体防治膝骨关节炎与骨质疏松症"共病"机制研究进展
- Author:
Yuanchao ZOU
1
;
Runyu YIN
1
;
Haoyu YANG
1
;
Changrong MA
1
;
Aifeng LIU
1
;
Yuandong LI
1
Author Information
1. 天津中医药大学第一附属医院,天津 300381;国家中医针灸临床医学研究中心,天津 300381
- Publication Type:Journal Article
- Keywords:
knee osteoarthritis;
osteoporosis;
exosome;
Chinese materia medica;
co-morbidity;
review
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(9):186-191
- CountryChina
- Language:Chinese
-
Abstract:
Knee osteoarthritis(KOA)and osteoporosis(OP)"co-morbidity"is a chronic progressive disease,the incidence of which is higher in recent years.Exosomes have intercellular messenger functions,which play an important role in the development of KOA and OP"co-morbidity".This article recognized the"co-morbidity"between KOA and OP from the perspective of modern medicine and the"tendon","bone","liver"and"kidney"in TCM theories,systematically reviewed the indirect regulation of KOA and OP"co-morbidity"through exosomes,and explored the possible mechanisms of exosome-based treatment of KOA and OP"co-morbidity"through Chinese materia medica in terms of inflammation,MAPK pathway,bone remodeling and cartilage metabolism,and mitochondrial autophagy,with the aim to investigate the possible mechanisms of KOA and OP"co-morbidity",and provide new ideas for the treatment of KOA and OP"co-morbidity".
