Expression and significance of miR-223,bFGF and MCP-1 in patients with colostomy infection following rectal cancer surgery
10.11816/cn.ni.2025-242058
- VernacularTitle:直肠癌术后结肠造口感染患者miR-223及bFGF与MCP-1的表达及意义
- Author:
Huifei ZHAI
1
;
Jixia LIANG
;
Jinjin WAN
;
Fangjie CHEN
Author Information
1. 浙江中医药大学护理学院,浙江 杭州 310053;浙江省人民医院(附属人民医院)门诊,杭州医学院,浙江 杭州 310000
- Publication Type:Journal Article
- Keywords:
Rectal cancer;
Colostomy infection;
MicroRNA-223;
Monocyte chemoattractant protein-1;
Basic fibro-blast growth factor
- From:
Chinese Journal of Nosocomiology
2025;35(15):2300-2304
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the expression and clinical significance of microRNA-223(miR-223),mono-cyte chemoattractant protein-1(MCP-1),and basic fibroblast growth factor(bFGF)in patients with colostomy infection after rectal cancer surgery.METHODS One hundred patients with rectal cancer who underwent surgery in Zhejiang Provincial People's Hospital between Jun.2022 and Jun.2024 were chosen retrospectively and divided in-to an infection group(n=27)and a non-infection group(n=73)based on whether colostomy infection occurred within seven days after surgery.The etiological features of postoperative hospital-acquired infection were analyzed,and the differences in serum miR-223,bFGF,and MCP-1 levels between the infected and non-infected groups were detected.The receiver operating characteristic(ROC)curve was used to analyze the predictive values of ser-um miR-223,bFGF,and MCP-1 for postoperative colostomy infection.RESULTS A total of 30 pathogenic strains were isolated from 27 patients in the infection group,including 17 gram-negative bacteria(56.67%),11 gram-positive bacteria(36.67%),and 2 fungi(6.67%),with Escherichia coli being the most common.The serum lev-els of miR-223 and MCP-1 were higher in the infected group than those in the non-infected group,while bFGF was lower in the infected group(P<0.05).The ROC curve analysis showed that the area under the curve(AUC)for the combined detection of serum miR-223,bFGF,and MCP-1 was 0.944,with the sensitivity of 88.88%and spe-cificity of 94.52%.CONCLUSIONS Postoperative colostomy infection in rectal cancer patients is primarily caused by E.coli and is associated with changes in serum miR-223,bFGF and MCP-1 levels.Abnormally high expression of miR-223 and MCP-1 and abnormally low expression of bFGF can predict postoperative colostomy infection in rectal cancer,which can provide an important basis for clinical diagnosis of postoperative infections in the rectal cancer patients.
