Discussion on the Effects of Reprogramming of Glucose Metabolism Induced Macrophage Polarization on Myocardial Ischemia from the Theory of"Deficient Qi Stagnation"
10.19879/j.cnki.1005-5304.202409473
- VernacularTitle:从"虚气留滞"理论探讨糖代谢重编程诱导巨噬细胞极化对心肌缺血的影响
- Author:
Meng YANG
1
;
Siyuan HU
1
;
Lin LI
1
;
Zhixi HU
1
Author Information
1. 湖南中医药大学中医学院,湖南 长沙 410208
- Publication Type:Journal Article
- Keywords:
myocardial ischemia;
glucose metabolism reprogramming;
macrophage polarization;
deficient qi stagnation
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(9):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are central mediators of cardiac inflammation and are involved throughout the development of myocardial ischemia.Glucose metabolism reprogramming is an event that affects the core of macrophage polarization,and it can alter the phenotype of macrophages by regulating their glycolytic modes,which in turn affects myocardial injury-repair process.This study sorted out pathogenesis of"deficient qi stagnation"and the related study of macrophage polarization induced by glucose metabolism reprogramming,combined with the overall diagnosis and microscopic point of view,and proposed that myocardial ischemia lies in the cardiac collaterals and the accumulation of pathological products due to abnormal reprogramming of macrophage glucose metabolism in the pathogenesis of myocardial ischemia,which is similar to TCM theory of"deficient qi stagnation".The increase of inflammatory factors in myocardial ischemia and the outcome of ventricular remodeling caused by macrophage polarization imbalance can be regarded as the"toxic damage"process of heart.In the clinical practice,the method of"supporting the healthy qi and replenishing the deficiency,and eliminating the stagnation and detoxification"is used to improve the reprogramming of glucose metabolism,remodel the polarization of macrophages,reduce the inflammatory reaction,and delay the progression of the disease.Therefore,the use of TCM therapy to regulate glucose metabolism reprogramming to induce macrophage polarization is expected to bring new therapeutic ideas for myocardial ischemia.
