Impact of carbon ion radiotherapy on immune response
10.12354/j.issn.1000-8179.2025.20250781
- VernacularTitle:碳离子放射治疗对免疫反应的影响
- Author:
Yu RONG
1
;
Xiong XIANGZHI
;
Pan TINGTING
;
Liu QIANG
;
Liu YUAN
;
Dong JINGJING
;
Chen WEIZUO
Author Information
1. 甘肃省武威肿瘤医院放疗六科(甘肃省 武威市 733000)
- Publication Type:Journal Article
- Keywords:
carbon ion radiotherapy(CIRT);
innate immunity;
adaptive immunity;
immunotherapy
- From:
Chinese Journal of Clinical Oncology
2025;52(14):748-752
- CountryChina
- Language:Chinese
-
Abstract:
Carbon ion radiotherapy(CIRT)is an advanced radiotherapy method with unique physical and biological properties.It increases the dose to the tumor target area while providing better protection to normal tissues.CIRT can be used for hypoxic tumors resistant to photon radiotherapy.It also has the potential superiority of inducing immune responses and can produce the"abscopal effect"when com-bined with different immunotherapies.Radioimmunotherapy can not only ablate tumors at the irradiated site but also partially control dis-tant metastases at the unirradiated site.However,the underlying mechanism has not been fully elucidated.Due to the protection of the tu-mor microenvironment,tumors can sometimes be difficult to completely clear through CIRT-mediated anti-tumor immunity;this can also in-dicate functional limitations of some immune organs after CIRT.Therefore,this study reviewed the impact of CIRT on both innate and adapt-ive immune responses.It also examined the relationship between different radiation doses/fractions and immune protein expression,as well as compared the differences in imaging techniques between carbon ion radiotherapy and traditional radiotherapy.We have also proposed future directions to enhance the superiority of CIRT.This study aimed to provide a strong theoretical basis for improving the efficacy of CIRT and its combination therapy,ultimately benefiting more patients with cancer.
