Effect of dexmedetomidine nasal spray on perioperative sleep quality and anxiety stress in patients undergoing hysterectomy
10.3969/j.issn.1673-9701.2025.22.017
- VernacularTitle:右美托咪定鼻喷雾剂对子宫切除术患者围手术期睡眠及焦虑应激的影响
- Author:
Zhi ZHENG
1
;
Yiping YANG
;
Yiyi DING
;
Yangyang WANG
;
Wenwei WANG
;
Jun LI
Author Information
1. 台州市第一人民医院麻醉科,浙江台州 318020
- Publication Type:Journal Article
- Keywords:
Hysterectomy;
Dexmedetomidine;
Nasal spray;
Sleep;
Anxiety;
Stress
- From:
China Modern Doctor
2025;63(22):73-76,108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of dexmedetomidine nasal spray(DNS)on perioperative sleep quality,anxiety stress in patients undergoing hysterectomy.Methods A total of 75 patients who underwent laparoscopic hysterectomy at Taizhou First People's Hospital from May to December 2024 were selected and divided into control group(37 cases)and experimental group(38 cases)according to the random number table method.Patients in experimental group were respectively sprayed with 50μg or 75pg of DNS at 20:30 on the night before surgery and the night after surgery,patients in control group were respectively given an equal volume of normal saline nasal spray at 20:30 on the night before surgery and the night after surgery.Athens insomnia scale(AIS)scores and sleep quality on the first night of admission(T0),the first night before surgery(T1),the first night after surgery(T2),and the second night after surgery(T3),the scores of hospital anxiety and depression scale(HADS),salivary cortisol andα-amylase on the first day of admission,before entering the operating room,and on the first and second days after surgery,and incidence of adverse reactions 60 minutes after administration between two groups of patients were observed and compared.Results Compared with control group,the AIS scores in experimental group at T1,T2 and T3 were significantly lower,the latency to sleep was significantly shortened,the total sleep time and non-rapid eye movement sleep time were significantly prolonged,and rapid eye movement sleep time was significantly shortened(P＜0.05),number of awakenings at T1 and T2 decreased significantly(P＜0.05),and HADS score,salivary cortisol and α-amylase levels before entering the operating room,and on the first and second days after surgery were all significantly decreased(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions within 60 minutes after administration between two groups of patients(P＞0.05).Conclusion Perioperative administration of DNS can significantly improve the sleep quality of patients undergoing laparoscopic hysterectomy,relieve anxiety,reduce stress levels,and has high safety.
