Based on data mining and network pharmacology,explore the medication patterns and mechanisms of action for functional dyspepsia in children
10.3969/j.issn.1673-9701.2025.22.015
- VernacularTitle:基于数据挖掘和网络药理学探究小儿功能性消化不良的用药规律与作用机制
- Author:
Dongqing CHEN
1
;
Yiwei WU
;
Jiaping FAN
;
Yindi ZHU
;
Jie CHEN
Author Information
1. 温州医科大学附属第二医院药学部,浙江温州 325024
- Publication Type:Journal Article
- Keywords:
Functional dyspepsia;
Children;
Data mining;
Network pharmacology
- From:
China Modern Doctor
2025;63(22):63-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective The medication pattern of doctor Chen Jie in treating functional dyspepsia(FD)in children and the potential mechanism of action of core drug group were explored through data mining and network pharmacology methods.Methods The prescriptions for pediatric FD treated by doctor Chen Jie in the outpatient department of Second Affiliated Hospital of Wenzhou Medical University from January 2020 to December 2024 were collected to establish a prescription database.Excel 2019 and SPSS software were applied to statistically analyze the nature,taste,meridian tropism and frequency of drugs included in the prescriptions,and association rule analysis and cluster analysis were conducted.The potential mechanism of action of the core drug group was explored by using the network pharmacology method.Results A total of 603 prescriptions were included,involving 160 kinds of drugs,with a cumulative frequency of medication reaching 5012 times.Among them,the medicinal nature and flavour were mainly warm and sweet,and channel tropism were mainly the spleen,stomach and lung meridians.The core drug group obtained through association rules and cluster analysis was"Fuchao Baizhu-Fuling-Chenpi".Network pharmacological analysis was conducted on the core drug group,and it was found that its main components included naringenin,atractylenolide Ⅰ,atractylone,and hederagenin,as well as core genes such as AKT1,TNF,IL-6,ESR1,and IL-1β.The main enrichment pathways were lipids and atherosclerosis,advanced glycation end product-advanced glycation end product receptor signaling pathway,cancer pathway,etc..Conclusion Doctor Chen Jie's medication for treating FD in children mainly focuses on invigorating spleen and replenishing qi,regulating qi-flowing for eliminating dampness.The core drug group,"Fuchao Baizhu-Fuling-Chenpi",exerts its effects through multiple components,multiple targets and multiple pathways.
