Risk factors and prognostic analysis of early myocardial injury after acute carbon monoxide poisoning
10.3969/j.issn.1673-9701.2025.22.006
- VernacularTitle:急性一氧化碳中毒后早期心肌损伤的危险因素及预后分析
- Author:
Yi ZHONG
1
;
Jianyi LIU
1
;
Yan LIU
1
;
Yunchun GAO
1
;
Ling JIN
1
Author Information
1. 中南大学湘雅医学院附属常德医院神经内科,湖南常德 415000
- Publication Type:Journal Article
- Keywords:
Acute carbon monoxide poisoning;
Early myocardial injury;
Aspartate aminotransferase;
C-reactive protein
- From:
China Modern Doctor
2025;63(22):21-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors of early myocardial injury in patients with acute carbon monoxide poisoning(ACOP)and the effect of myocardial injury on prognosis.Methods A total of 176 patients with ACOP who were hospitalized in Changde Hospital Affiliated to Xiangya School of Medicine,Central South University from January 2020 to November 2024 were selected.According to the highest value of MB isoenzyme of creatine kinase(CK-MB)within 72h after poisoning,the patients were divided into early myocardial injury group(CK-MB ≥ 75 U/L,32 cases)and non-early myocardial injury group(CK-MB＜75 U/L,144 cases).The clinical data of two groups were collected and compared,and independent influencing factors of early myocardial injury in patients with ACOP were explored by applying the multivariate Logistic regression model.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficacy of its risk factors for early myocardial injury.Results The neutrophil to lymphocyte ratio,monocyte to lymphocyte ratio,alanine aminotransferase,aspartate aminotransferase(AST),blood urea nitrogen and C-reactive protein(CRP)of patients with early myocardial injury group were significantly higher than those of non-early myocardial injury group(P＜0.05).Multivariate Logistic regression analysis showed that both AST and CRP were independent risk factors for early myocardial injury in patients with ACOP(P＜0.05).The sensitivity of AST combined with CRP in predicting early myocardial injury in patients with ACOP was 78.1％,the specificity was 93.1％,and area under the curve was 0.931.The incidence of delayed encephalopathy in early myocardial injury group was significantly higher than that in non-early myocardial injury group(x2=19.055,P＜0.001).Conclusion AST and CRP are independent risk factors for early myocardial injury in ACOP patients,and AST combined with CRP has a certain predictive value for early myocardial injury in ACOP patients.The incidence of delayed encephalopathy was higher in patients with early myocardial injury,suggesting that myocardial injury is closely related to the poor prognosis of patients.
