Research progress of human monoclonal antibodies targeting influenza virus neuraminidase

VernacularTitle:靶向流感病毒神经氨酸酶的人源单克隆抗体研究进展
Author: Yanbai LI ¹ ; Chunying WANG ; Zhe YIN ; Qingan HAN ; Yixin GONG ; Juan WANG ; Shanshan HUO ; Fei YU
Author Information

1. 河北农业大学生命科学学院,河北保定 071001
Publication Type:Journal Article
Keywords: Influenza virus; Neuraminidase; Monoclonal antibody; Mechanism of action; Anti-influenza Drugs
From: Chinese Journal of Nosocomiology 2025;35(16):2556-2560
CountryChina
Language:Chinese
Abstract: Neuraminidase(NA),a glycoprotein on the surface of the influenza virus,plays a crucial role in viral escape and serves as a stable target for drug candidates.Monoclonal antibodies targeting the NA active site can bind to multiple influenza virus subtypes and inhibit the spread of influenza virus through various mechanisms,such as neutralizing,mediating antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotox-icity.In vivo experiments have shown that human monoclonal antibodies targeting the influenza virus NA can ef-fectively exert preventive and therapeutic effects,rescuing mice infected with lethal doses and reducing viral ti-ters in lungs of mice.This article provides a review of the currently reported human monoclonal antibodies targe-ting NA of Influenza A and Influenza B viruses,providing new ideas and prospects for the subsequent development of anti-influenza drugs.