Research progress on resistance mechanism and evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae
10.11816/cn.ni.2025-242144
- VernacularTitle:碳青霉烯类耐药高毒力肺炎克雷伯菌耐药机制及进化研究进展
- Author:
Jiawei DING
1
;
Mengying ZHANG
;
Zidan HU
;
Qingrong LI
;
Ying ZHOU
;
Jia WANG
;
Lei FENG
Author Information
1. 昆明医科大学附属延安医院检验科,云南 昆明 650051
- Publication Type:Journal Article
- Keywords:
Klebsiella pneumoniae;
Carbapenems;
Carbapenem-resistant hypervirulent Klebsiella pneumoniae;
Resistance mechanism;
Evolution
- From:
Chinese Journal of Nosocomiology
2025;35(16):2535-2540
- CountryChina
- Language:Chinese
-
Abstract:
Klebsiella pneumoniae,as a clinically prevalent opportunistic pathogen,ranks as the second most com-monly detected pathogen in clinical isolates in China.The extensive clinical use of carbapenem antibiotics has led to a high global detection rate of carbapenem-resistant K.pneumoniae(CRKP).Characterized by complex resist-ance mechanisms and diverse evolutionary pathways,CRKP infections pose significant challenges in prevention and treatment,with high associated mortality rates,creating substantial obstacles for clinical anti-infective therapy.In recent years,the emergence and global spread of carbapenem-resistant hypervirulent K.pneumoniae(CR-hvKP)have escalated into a major public health threat.Notably,hypervirulent K.pneumoniae isolates carry-ing carbapenem resistance genes are rapidly disseminating worldwide,causing fatal infections even in immunocom-petent individuals.This article systematically reviews the latest research advances on the resistance mechanisms,evolutionary pathways,adaptive changes,and clinical management strategies of CR-hvKP,aiming to deepen un-derstanding of this"superbug"and provide a theoretical foundation for clinical prevention and control.
