Differences in mercury dissolution from HgS-containing traditional medicines under simulated gastrointestinal conditions
10.3969/j.issn.1001-1528.2025.08.019
- VernacularTitle:含硫化汞传统药物在模拟胃肠道条件下的汞溶出差异
- Author:
Ming ZHANG
1
;
Yuan-can XIAO
;
Jing ZHAO
;
Hai-ying TONG
;
Xiao-yu WANG
;
Wen-bin ZHOU
;
Hong-tao BI
;
Li-xin WEI
Author Information
1. 中国科学院西北高原生物研究所,青海西宁 810008
- Publication Type:Journal Article
- Keywords:
mercury sulfide;
traditional medicines;
simulated gastric fluid;
simulated intestinal fluid;
L-cysteine;
soluble mercury
- From:
Chinese Traditional Patent Medicine
2025;47(8):2607-2611
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the variations in mercury dissolution from HgS-containing traditional medicines in three kinds of simulated gastrointestinal dissolution media.METHODS 39 batches of 15 types of HgS-containing traditional medicines were collected,total mercury content and dissolved mercury concentrations in simulated gastric fluid,simulated intestinal fluid,and L-cysteine-containing simulated intestinal fluid were measured.The maximum daily intake of total mercury and soluble mercury was calculated based on the maximum daily clinical dosage.RESULTS Among the 15 types of medicines,the maximum daily intake of total mercury varied by 156 times,the daily intake of soluble mercury varied by 3 502 times in simulated gastric fluid,313 times in simulated intestinal fluid,and 10 663 times in L-cysteine-containing simulated intestinal fluid,approximately.CONCLUSION For the 15 types of HgS-containing traditional medicines,the daily maximum intake of soluble mercury showed greater variations than that of total mercury.Soluble mercury concentration is more closely correlated with intestinal absorption of mercury and thus represents a more rational quality control indicator for HgS-containing traditional medicines.
