Preparation of borneol-menthol eutectic mixture-loaded nanoemulsion gel of tetramethylpyrazine
10.3969/j.issn.1001-1528.2025.08.006
- VernacularTitle:冰片-薄荷脑低共熔物载川芎嗪纳米乳凝胶制备
- Author:
Jing WEN
1
;
Jun-song NIU
1
;
Yu-zhen WU
1
;
Jie DENG
1
;
Nan LI
1
Author Information
1. 成都中医药大学药学院,西南特色中药资源国家重点实验室,四川成都 611137
- Publication Type:Journal Article
- Keywords:
tetramethylpyrazine;
nanoemulsion gel;
eutectic mixture;
borneol;
menthol;
preparation
- From:
Chinese Traditional Patent Medicine
2025;47(8):2522-2529
- CountryChina
- Language:Chinese
-
Abstract:
AIM To prepare the borneol-menthol eutectic mixture-loaded nanoemulsion gel of tetramethylpyrazine.METHODS The equilibrium solubilities of tetramethylpyrazine in different oil phases,emulsifiers and co-emulsifiers were determined,after which compatibility experiment was performed,and pseudo-ternary phase diagram was drawn.With Km value,oil phase proportion and water phase consumption as influencing factors,particle size,PDI and saturated drug loading as evaluation indices,the formulation was optimized by central composite design-response surface method.The drug-loaded nanoemulsion was dispersed into carbomer 940 gel matrix to prepare nanoemulsion gel,then the physicochemical properties,in vitro drug release and transdermal absorption properties were investigated.RESULTS The optimal formulation was determined to be 3.31∶6.16∶1.56∶88.97 for eutectic mixture-EL-40-1,2-propylene glycol-water ratio,the particle size,PDI and saturated drug loading were 37.85 nm,23.04 and 5.82 mg/g,respectively.The obtained white,semi-solid nanoemulsion gel demonstrated the average pH value and viscosity of 6.68±0.07 and(289.69±1.06)mPa·s,respectively,whose in vitro drug release accorded with Higuchi equation,and the accumulative permeability per unit area was(2 048.23±55.6)μg/cm2 within 24 h,which were 3.72 and 1.21 times higher than those of hydrogel and aqueous solution,respectively.CONCLUSION The borneol-menthol eutectic mixture-loaded nanoemulsion gel of tetramethylpyrazine meets preparation requirements,thus can achieve the effective transdermal delivery of raw medicine.
