The combined prognostic value of MSI,DD,and CA1 9-9 in colorectal cancer patients who underwent radical resection
10.3969/j.issn.1673-9701.2025.24.011
- VernacularTitle:MSI、DD、CA19-9联合评估结直肠癌根治术预后的价值
- Author:
Yiqian WU
1
;
Zhenbo FENG
;
Jie HU
Author Information
1. 广西医科大学第一附属医院病理科,广西南宁 530021
- Publication Type:Journal Article
- Keywords:
Microsatellite instability;
D-dimer;
CA19-9;
Colorectal cancer;
Prognosis
- From:
China Modern Doctor
2025;63(24):50-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognostic value of microsatellite instability(MSI),preoperative D-dimer(DD),and CA19-9 level for the prognosis of colorectal cancer(CRC)patients who had undergone radical resection.Methods Retrospectively analyzed the general clinical data,MSI,DD,and CA19-9 levels of 81 CRC patients who underwent radical resection in the First Affiliated Hospital of Guangxi Medical University and Guilin People's Hospital between January 2020 and December 2021.Screen and evaluate prognostic factors.Results There was a statistically significant difference in the incidence of MSI,preoperative DD,and CA19-9 expression levels between recurrence group and non recurrence group(P＜0.05).There was a statistically significant difference in the incidence of MSI,preoperative DD,and CA19-9 expression levels between death group and survival group(P＜0.05).Univariate and multivariate analyses MSI was identified as a protective factor against recurrence(P=0.018),and high levels of preoperative DD and CA1 9-9 were identified as independent risk factors for recurrence(P=0.020,P=0.042).MSI was identified as a protective factor against mortality in CRC patients(P=0.036),and high levels of preoperative DD and CA19-9 were identified as independent risk factors for mortality in CRC patients(P=0.010,P=0.017).The receiver operating characteristic curve showed that the area under the curve(AUC)of MSI,DD,and CA19-9 for predicting recurrence after CRC surgery were 0.643,0.599,and 0.644 respectively,for mortality,they were 0.646,0.642,and 0.693 respectively.The combined model for predicting recurrence and mortality yielded AUC were 0.776 and 0.825,respectively.Conclusion MSI is a protective factor for prognosis in CRC patients,whereas high levels of preoperative DD and CA19-9 are risk factors for poor prognosis.The combined detection of these three factors can optimize the risk stratification of CRC.
