Mitochondrial Function in Relationship of"Xuanfu Obstruction and Lung Collateral Damage"with Airway Remodeling in Chronic Obstructive Pulmonary Disease
10.16466/j.issn1005-5509.2025.10.005
- VernacularTitle:基于线粒体功能探讨"玄府郁闭、肺络受损"与慢性阻塞性肺疾病气道重塑的关系
- Author:
Jiayang LI
1
;
Shuangyu CHEN
;
Yinying CHAI
Author Information
1. 浙江中医药大学第一临床医学院 杭州 310053
- Publication Type:Journal Article
- Keywords:
mitochondria;
Xuanfu;
lung collateral;
chronic obstructive pulmonary disease;
airway remodeling;
oxidative stress;
metabolic imbalance;
treatment of traditional Chinese medicine
- From:
Journal of Zhejiang Chinese Medical University
2025;49(10):1248-1254
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigates the pathogenesis and clinical management of airway remodeling in chronic obstructive pulmonary disease(COPD)through the lens of mitochondrial functionality,based on the theoretical framework of"Xuanfu".[Methods]Through review of modern literature and classical Chinese medical ancient books it explores the link between mitochondrial dysfunction and COPD airway remodeling,examines how the"Xuanfu"theory relates to mitochondrial function in both physiological and pathological contexts,discusses the traditional Chinese medical(TCM)pathogenesis of COPD airway remodeling,summarizes treatment principles,and highlights contemporary studies supporting the role of TCM in modulating mitochondrial function.[Results]Mitochondrial dysfunction is crucial in COPD airway remodeling,with mechanisms and clinical manifestations aligning with"Xuanfu obstruction"and"lung collateral damage"in TCM.Based on the"Xuanfu"theory,the core pathogenesis can be described as"Xuanfu obstruction,lung collateral damage".The treatment should focus on utilizing pungent agents to disperse and ventilate,regulating Qi to open Xuanfu portals,expelling phlegm and resolving static blood,alleviating depression to free collateral vessels,reinforcing healthy Qi while eliminating pathogenic factors,strategically harmonizing unblocking with tonifying interventions.Contemporary studies indicate that intervention with traditional Chinese herbal formulas may repair pulmonary tissue damage and inhibit airway remodeling.These effects are mediated through mechanisms including the enhancement of mitochondrial energy metabolism and the promotion of mitophagy and mitochondrial biogenesis.These findings provide a modern scientific basis for the traditional pathogenesis of"Xuanfu obstruction,lung collateral damage"and its corresponding therapeutic principles in TCM.[Conclusion]The thesis propose mitochondrial dysfunction as the key pathophysiological link between the TCM mechanism of"Xuanfu obstruction,lung collateral damage"and airway remodeling in COPD.This framework establishes mitochondrial homeostasis as a core therapeutic target for TCM interventions,offering a novel basis for integrating traditional theory with modern cellular mechanisms in COPD diagnosis and treatment.
