Efficacy of Warm Acupuncture Combined with Guizhi Shaoyao Zhimu Decoction in the Treatment of Knee Osteoarthritis and Its Influence on Synovial Hyperplasia
10.16466/j.issn1005-5509.2025.10.012
- VernacularTitle:温针灸辅助桂枝芍药知母汤治疗膝关节骨性关节炎的疗效及对关节滑膜增生的影响
- Author:
Guanglin LI
1
;
Jie FANG
1
;
Jia'an WANG
1
Author Information
1. 南京市中西医结合医院 南京 210018
- Publication Type:Journal Article
- Keywords:
knee osteoarthritis;
Guizhi Shaoyao Zhimu Decoction;
warming acupuncture and moxibustion;
synovial hyperplasia of joints;
bone numbness;
wind-cold-dampness Bi syndrome;
inflammatory factors;
knee flexion angle
- From:
Journal of Zhejiang Chinese Medical University
2025;49(10):1294-1299
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To explore the efficacy of warm acupuncture combined with Guizhi Shaoyao Zhimu Decoction in the treatment of knee osteoarthritis and its effect on synovial hyperplasia.[Methods]A total of 106 patients with knee osteoarthritis treated at the Nanjing Integrated Traditional Chinese and Western Medicine Hospital from January 2022 to January 2024 were selected and randomly divided into two groups by using a computer-generated random number method,53 patients in observation group and 53 patients in control group.The control group was treated with Guizhi Shaoyao Zhimu Decoction,while the observation group received Guizhi Shaoyao Zhimu Decoction combined with warm acupuncture.After one month of treatment,the traditional Chinese Medicine(TCM)syndromes,knee joint function,inflammatory factors including tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),matrix metalloproteinase-3(MMP-3),synovial hyperplasia indicators such as cartilage oligomeric matrix protein(COMP),osteoprotegerin(OPG)and fibroblast growth factor-2(FGF-2)were compared between the two groups.The therapeutic efficacy and adverse reactions were also evaluated.[Results]After treatment,the joint pain,difficulty in extension and flexion,exacerbation in cold weather and heaviness of the limbs in both groups decreased,with observation group showing significantly lower scores than control group(P<0.05).After treatment,the Lysholm knee function score,knee flexion angle,OPG and FGF-2 levels in observation group were higher than those in control group(P<0.05),while COMP was lower(P<0.05).The levels of TNF-α,IL-1 and MMP-3 decreased in both groups,with observation group showing lower levels than control group(P
