Correlation between AST/ALT ratio and metabolic syndrome in hypertensive patients
10.3969/j.issn.1673-9701.2025.23.004
- VernacularTitle:高血压患者AST/ALT比值与代谢综合征的相关性研究
- Author:
Ling WANG
1
;
Yan LUO
;
Maozhen FU
;
Ling ZHANG
;
Weiliang ZHU
;
Hong HUANG
;
Jiaze TAN
;
Yiping LAI
;
Liuyun CHENG
Author Information
1. 深圳市坪山区疾病预防控制中心慢性病防治所,广东 深圳 518118
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome;
Hypertension;
Alanine aminotransferase;
Aspartate aminotransferase
- From:
China Modern Doctor
2025;63(23):14-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio and metabolic syndrome(MS)in elderly hypertensive patients,and to provide reference for early detection and prevention of MS in elderly hypertensive patients.Methods A questionnaire survey and physical examination were conducted among 616 elderly hypertensive patients at community health service centers.Participants were divided into two groups based on MS status:MS group(n=334)and non-MS group(n=282).According to AST/ALT levels,participants were divided into four groups:q1 group(AST/ALT ≤0.88,n=156),q2 group(0.88＜AST/ALT ≤ 1.10,n=155),q3 group(1.10＜AST/ALT ≤ 1.37,n=154),and q4 group(AST/ALT＞1.37,n=151).Blood biochemical parameters including triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),AST,ALT,and blood glucose were measured.The impact of AST/ALT levels on MS was analyzed using a Logistic regression model,while the risk prediction for MS occurrence was evaluated through receiver operating characteristic(ROC)curves.Results MS group showed higher body mass index(BMI),TG,ALT levels,abnormal glucose levels,female proportion,and abdominal obesity rate compared to non-MS group.HDL-C and AST/ALT values of MS group were lower than those in non-MS patients(P＜0.05).Logistic regression analysis revealed that after adjusting for BMI,smoking,alcohol consumption,physical activity,education level,marital status,TG,HDL-C,and glucose levels,both q3 and q4 groups demonstrated reduced MS risk compared to group q1 group(P＜0.05).ROC curve analysis indicated that the area under the curve for AST/ALT in MS was 0.638(P＜0.05).Conclusion The level of AST/ALT was negatively correlated with MS in elderly hypertensive patients,and AST/ALT has certain predictive value for the risk of MS in elderly hypertensive patients.
