Clinical characteristics and related risk factors analysis of severe Mycoplasmal pneumoniae pneumonia in children
10.3969/j.issn.1673-9701.2025.24.009
- VernacularTitle:儿童重症肺炎支原体肺炎的临床特点及其相关危险因素分析
- Author:
Hailing HE
1
;
Jianliang LU
1
;
Yuan FENG
1
;
Yanling LU
1
Author Information
1. 中山大学附属第一医院广西医院儿科,广西南宁 530022
- Publication Type:Journal Article
- Keywords:
Mycoplasmal pneumoniae pneumonia;
Severe;
Risk factors;
Children
- From:
China Modern Doctor
2025;63(24):39-43
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and related risk factors of severe Mycoplasmal pneumoniae pneumonia(SMPP)in children.Methods Analysis of clinical data of 240 children with Mycoplasmal pneumoniae pneumonia admitted to Guangxi Hospital Division of the First Affiliated Hospital,Sun Yat-sen University from October 2023 to March 2024.According to the severity of the disease,they were divided into SMPP group and general Mycoplasmal pneumoniae pneumonia(GMPP)group,multivariate Logistic regression analysis was used to analyze the risk factors related to the occurrence of SMPP.The receiver operating characteristic(ROC)curve was plotted to analyze the predictive value of each independent risk factor of SMPP.Results Compared the data during hospitalisation between GMPP group and SMPP group,the SMPP group had longer fever course,hospitalization time,azithromycin treatment time,and glucocorticoid use time(P＜0.05).The proportion of patients with unilateral lung lesions and large patchy shadows in SMPP group were significantly higher than those in GMPP group(P＜0.05).The levels of C-reactive protein,interleukin(IL)-6,and D-dimer in SMPP group were significantly higher than those in GMPP group,while the peripheral blood lymphocyte count was significantly lower than that in GMPP group(P＜0.05).The results of multiple Logistic regression analysis showed that the duration of fever,D-dimer,IL-6,and large patchy shadows in the lungs were independent risk factors for SMPP.The ROC curve results showed that fever duration ≥ 6.5 days,D-dimer≥0.495mg/L,IL-6≥11.05pg/ml,and large patchy shadows in the lungs had good application value in distinguishing SMPP and GMPP children.Conclusion Prolonged fever duration(≥6.5 days),significantly elevated levels of D-dimer and IL-6,and large patchy shadows in the lungs are the main clinical features of children with SMPP,which may be independent risk factors for predicting SMPP.
