Analysis of risk factors for the first occurrence of gastrointestinal bleeding in hepatitis B cirrhosis
10.3969/j.issn.1673-9701.2025.23.007
- VernacularTitle:乙肝肝硬化首次并发消化道出血的危险因素分析
- Author:
Shuhan ZHANG
1
;
Peng YANG
;
Zhengwu YANG
Author Information
1. 山东第一医科大学(山东省医学科学院)研究生部,山东济南 250117
- Publication Type:Journal Article
- Keywords:
Hepatitis B cirrhosis;
Gastrointestinal bleeding;
Risk factors;
Predictive modeling
- From:
China Modern Doctor
2025;63(23):28-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the risk factors and construct a predictive model for the first occurrence of gastrointestinal bleeding in patients with hepatitis B cirrhosis.Methods A total of 142 patients with hepatitis B cirrhosis admitted to the Second Affiliated Hospital of Shandong First Medical University from January 2023 to December 2024 were selected as subjects.Patients with first occurrence of gastrointestinal bleeding were classified as bleeding group(n=52),while patients without such history were devided into no bleeding group(n=90).Baseline data between groups were compared,and potential risk factors for the first occurrence of upper gastrointestinal bleeding in patients with hepatitis B cirrhosis were analyzed.Results Grade C liver function classification,low red blood cell count(RBC),thrombocytopenia,prolonged fibrinogen concentration,serum albumin,prothrombin activity,and prothrombin time,high international standardized ratio,widened main portal vein diameter,and severe esophageal/gastric varices were the risk factors for the first occurrence of gastrointestinal bleeding in patients with hepatitis B cirrhosis(P＜0.05).Multivariate Logistic analysis demonstrated that RBC,portal vein diameter,and severe esophageal/gastric varices were independent risk factors for gastrointestinal bleeding in hepatitis B cirrhosis patients.Conclusion When RBC＜3.25×109/L,portal vein diameter＞14.5 mm and severe esophageal varices are present,the combined diagnosis has a high predictive value for the risk of first upper gastrointestinal bleeding in hepatitis B cirrhosis patients.
