Effect of Liuzijue combined with external treatment of traditional Chinese medicine on the efficacy and serum inflammation levels in stable COPD patients
10.3969/j.issn.1673-9701.2025.24.003
- VernacularTitle:六字诀联合中医外治法对COPD患者疗效及血清炎症水平的影响
- Author:
An'an ZHANG
1
;
Dandan HU
;
Jinmei ZHANG
;
Xinru ZHANG
Author Information
1. 浙江中医药大学第三临床医学院,浙江 杭州 310053
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Liuzijue;
Traditional Chinese medicine external therapy;
Inflammation
- From:
China Modern Doctor
2025;63(24):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of the Liuzijue combined with external treatment of traditional Chinese medicine on patients in stable chronic obstructive pulmonary disease(COPD)and its effects on inflammatory factors.Methods A total of 96 patients with COPD in the stable phase presenting with lung and spleen Qi deficiency syndrome were enrolled from the Third Affiliated Hospital of Zhejiang Chinese Medical University from July 2021 to December 2023.The patients were randomly divided into two groups with equal numbers.Control group received conventional Western medical treatment,while treatment group was administered the Liuzijue exercise combined with external treatment of traditional Chinese medicine in addition to conventional Western medical treatment.The intervention lasted for 8 weeks.Changes in traditional Chinese medicine syndrome scores,body mass index,air flow obstruction,dyspnea and exercise capacity(BODE)index,as well as serum levels of monocyte chemoattractant protein-1(MCP-1),interleukin(IL)-35,and IL-17 were observed before and after treatment in both groups.Results Compared with pre-treatment levels,both groups exhibited significant reductions in traditional Chinese medicine syndrome scores,BODE index,MCP-1,and IL-17 levels,along with a significant increase in IL-35 levels(P＜0.05).Post-treatment,treatment group demonstrated significantly lower BODE index,traditional Chinese medicine syndrome scores,MCP-1,and IL-17 levels,as well as higher IL-35 levels compared to control group(P＜0.05).Conclusion The combined application of Liuzijue with traditional Chinese medicine external therapy was shown to improve BODE index and traditional Chinese medicine syndrome scores in patients with stable COPD,while effectively reducing pro-inflammatory factors MCP-1 and IL-17 and elevating anti-inflammatory factor IL-35 levels.
