Efficacy of mouse injectable murine nerve growth factor combined with prednisone in the treatment of IFP
10.3969/j.issn.1673-9701.2025.23.013
- VernacularTitle:注射用鼠神经生长因子联合泼尼松治疗IFP的疗效
- Author:
Yan LANG
1
;
Yunfeng QIN
1
;
Yinjie LING
1
Author Information
1. 湖州市第一人民医院儿科,浙江湖州 313000
- Publication Type:Journal Article
- Keywords:
Mouse injectable murine nerve growth factor;
Prednisone;
Idiopathic facial palsy;
Glial cell line derived neurotrophic factor
- From:
China Modern Doctor
2025;63(23):54-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of murine nerve growth factor for injection combined with prednisone in the treatment of children with idiopathic facial palsy(IFP).Methods A total of 170 children with IFP admitted to Huzhou First People's Hospital between April 2022 and June 2023 were selected as subjects.The children were divided into control group(n=85)and experimental group(n=85)by lottery method.The control group was treated with prednisone,and the experimental group was treated with mouse injectable murine nerve growth factor+prednisone.The clinical efficacy,neurotrophic factor levels,red blood cell immune function,facial nerve function,and adverse reactions were compared between two groups.Results The total effective rate in experimental group was significantly higher than that in control group(P＜0.05).After treatment,the experimental group demonstrated greater levels of nerve growth factor,glial cell-derived neurotrophic factor(GDNF),red blood cell C3b receptor ring formation rate,compared to control group.the experimental group showed lower levels of red blood cell immune complex ring rate and H-B grade scale scores(P＜0.05).Conclusion The combination of mouse nerve growth factor and prednisone injection has a remarkable effect on IFP patients,improving GDNF level and red blood cell immune function,improving facial nerve function and high safety.
