Clinical and imaging manifestations of disseminated nontuberculous mycobacteria disease involved multiple skeletons of non-HIV-infected patients
10.13929/j.issn.1003-3289.2025.10.024
- VernacularTitle:非HIV感染多部位骨骼受累播散性非结核分枝杆菌病临床及影像学表现
- Author:
Xiaojian WEN
1
;
Jie LING
1
;
Quhua YIN
1
Author Information
1. 湖南省胸科医院放射科,湖南长沙 410013
- Publication Type:Journal Article
- Keywords:
nontuberculous mycobacteria;
tuberculosis,osteoarticular;
tomography,X-ray computed;
magnetic resonance imaging
- From:
Chinese Journal of Medical Imaging Technology
2025;41(10):1715-1719
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical and imaging manifestations of disseminated nontuberculosis mycobacteria(NTM)disease involved multiple skeletons of non-HIV-infected patients.Methods Totally 11 cases of non-HIV-infected patients with disseminated NTM involved multiple skeletons(NTM group)and 30 patients of bone tuberculosis with multisite skeletal involvement(TB group)were retrospectively analyzed.Clinical and imaging manifestations were analyzed and compared between groups.Results Nine cases(9/11,81.82％)in NTM group were found with systemic underlying disease,including 5 cases of chronic anemia,4 cases of rheumatic immune diseases and 1 case of gout.NTM group had longer disease duration,lower incidence of fever and soft tissue masses,lower hemoglobin and higher erythrocyte sedimentation rate than TB group(all P＜0.05).NTM group exhibited higher incidences of pulmonary patchy/linear shadows,"skip-like"manifestations in spine and patchy/nodular high-density shadows in the affected bones,but lower incidences of pulmonary hematogenous/bronchial dissemination foci,polymorphic lung lesions and bone destruction with sequestrum/surrounding soft tissue abscesses than TB group(all P＜0.05).The thoracic vertebrae,shoulder joints and pelvis were most commonly affected in NTM group,while the thoracic and lumbar vertebrae were most commonly affected in TB group.Significant difference of skeletal involvement site was found between groups(P=0.035).After drug treatment,the conditions of 9 cases(9/11,81.82％)in NTM group improved,with better outcomes in bone destruction and surrounding soft tissue swelling,and bone hardening was more obvious than before.Conclusion Disseminated NTM disease involved multiple skeletons in non-HIV-infected patients was prone to secondarily develop in those with chronic anemia and rheumatologic immune diseases,characterized by prolonged disease duration and mild pulmonary manifestations,often revealed multiple skeletons destruction in thoracic spine,shoulder joints and pelvis,distributed in a"skip-like"pattern,with or without bone sclerosis and adjacent soft tissue swelling.
