18F-FDG PET/CT for distinguishing intestinal diffuse large B-cell lymphoma and intestinal adenocarcinoma
10.13929/j.issn.1003-3289.2025.10.018
- VernacularTitle:18F-FDG PET/CT鉴别肠弥漫性大B细胞淋巴瘤与肠腺癌
- Author:
Han LIN
1
;
Jiao ZHOU
Author Information
1. 贵阳市花溪区人民医院放射科,贵州贵阳 550025
- Publication Type:Journal Article
- Keywords:
intestinal neoplasms;
lymphoma,large B-cell,diffuse;
adenocarcinoma;
positron-emission tomography;
diagnosis,differential
- From:
Chinese Journal of Medical Imaging Technology
2025;41(10):1691-1695
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of 18F-FDG PET/CT for distinguishing intestinal diffuse large B-cell lymphoma(DLBCL)and intestinal adenocarcinoma.Methods A total of 31 patients with intestinal DLBCL(DLBCL group)and 60 patients with intestinal adenocarcinoma(adenocarcinoma group)diagnosed by pathology were retrospectively enrolled.Univariate and multivariate logistic regression were used to analyze 18F-FDG PET/CT data,including lesions' PET/CT manifestations and 18F-FDG metabolic parameters(the maximum standard uptake value[SU Vmax],mean standard uptake value[SU Vmean],metabolic tumor volume[MTV]and total lesion glycolysis[TLG]),in order to screen out the independent differentiating factors for intestinal DLBCL and intestinal adenocarcinoma,based on which then a regression model was constructed,and its goodness of fit was evaluated.The efficacy of each single independent differentiating factor and the regression model for distinguishing intestinal DLBCL and intestinal adenocarcinoma were analyzed.Results Significant differences of lesion's number,involved sites,involved intestinal length and 18F-FDG metabolic parameters were found between groups(all P＜0.05).The number of lesions,involved intestinal length and lesions' SU Vmax were all the independent differentiating factors for intestinal DLBCL and intestinal adenocarcinoma(all P＜0.05),and the regression model constructed based on the above factors had a good fit(P=0.502).The area under the curve for distinguishing intestinal DLBCL and intestinal adenocarcinoma based on lesions' number,the involved intestinal length,SU Vmax and the regression model was 0.732,0.838,0.755 and 0.889,respectively.Conclusion 18F-FDG PET/CT could effectively distinguish intestinal DLBCL and intestinal adenocarcinoma.
