Research progress in the treatment of targeting breast cancer stem cells
10.3781/j.issn.1000-7431.2025.2302-0051
- VernacularTitle:靶向乳腺癌干细胞治疗的研究进展
- Author:
Xiangdong LIU
1
;
Bo LUO
Author Information
1. 华中科技大学同济医学院附属湖北肿瘤医院腹部放疗科,湖北 武汉 430079
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Cancer stem cell;
Molecular targeted therapy;
Biomarker;
Signaling pathway
- From:
Tumor
2025;45(3):297-306
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the incidence of breast cancer among Chinese women has been increasing annually,with its poor prognosis and high mortality rates presenting major challenges in current breast cancer treatment.Breast cancer stem cells(BCSCs)are the key factors which leading to the occurrence,development,treatment resistance,and recurrence of breast cancer.A high proportion of BCSCs are also closely related to adverse outcome of breast cancer patients.However,traditional drugs are difficult to effectively eliminate BCSCs and may even increase their enrichment level.Therefore,developing therapeutic strategies specifically targeting BCSCs represents a critical breakthrough for improving treatment efficacy in breast cancer patients.Significant progresses have been made in this field,including the development of various inhibitors targeting BCSCs surface markers,key signaling pathways,and immune checkpoints,as well as advances in nano-drug delivery systems(NDDS)and the discovery of numerous novel targets,offering new directions for breast cancer treatment.This paper systematically reviews recent advances and existing challenges in BCSCs-targeted therapies,and outlines future directions,aiming to provide new insights for both clinical practice and scientific research in breast cancer treatment.
