Predictive value of preoperative CT-based diagnosis of sarcopenia on the prognosis of patients with pancreatic cancer
10.3781/j.issn.1000-7431.2025.2312-0658
- VernacularTitle:基于术前CT诊断的肌减少症对胰腺癌患者预后的预测价值
- Author:
Chen CHEN
1
;
Ziyao WANG
;
Shuseng QIAN
Author Information
1. 四川省成都市中西医结合医院/成都市第一人民医院放射科,四川 成都 610041
- Publication Type:Journal Article
- Keywords:
Pancreatic cancer;
Sarcopenia;
CT;
Prognosis
- From:
Tumor
2025;45(3):269-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Exploring the predictive value of sarcopenia based on preoperative CT diagnosis for the prognosis of patients with pancreatic cancer.Methods:A retrospective analysis was conducted on the clinical,pathological,and imaging data of 488 patients who underwent radical resection for pancreatic cancer,to analyze the correlation between sarcopenia and the prognosis of patients with pancreatic cancer.Results:Among the 488 patients included,281 had sarcopenia before surgery and 207 did not.The COX proportional hazards regression model showed that sarcopenia was an independent risk factor for overall survival in pancreatic cancer patients[hazard ratio 1.43(95%confidence interval:1.02-1.99);P=0.04],while preoperative sarcopenia was not associated with postoperative disease-free survival(P>0.05).Conclusion:Sarcopenia diagnosed based on preoperative CT is significantly correlated with the overall survival of patients with pancreatic cancer after surgery and is an independent risk factor for the overall survival of patients with pancreatic cancer after surgery.
