Paternal transmission of epigenetic information and its potential impact on offspring health
10.13263/j.cnki.nja.2025.11.011
- VernacularTitle:父源性表观遗传信息的传递及其对子代健康的潜在影响
- Author:
Zilin ZHENG
1
;
Yifan ZHANG
;
Bingrou GUO
;
Liandong ZUO
Author Information
1. 广州医科大学附属妇女儿童医疗中心,广州 510623;广州医科大学研究生院,广州 511436
- Publication Type:Journal Article
- Keywords:
paternal exposure;
male infertility;
sperm;
environmental factors;
epigenetics;
offspring health
- From:
National Journal of Andrology
2025;31(11):1027-1031
- CountryChina
- Language:Chinese
-
Abstract:
Recent studies indicate that paternal exposures significantly affect offspring health.Adverse factors such as poor diet,toxin exposure,and stress can reduce semen quality and disrupt epigenetic marks in sperm,leading to changes in off-spring traits.Paternal transgenerational inheritance mainly occurs through epigenetic factors like DNA methylation,histone modi-fication,and non-coding RNAs.While researches have begun to reveal how sperm transmits epigenetic information,paternal epi-genetics largely remains correlational.Increasing concerns about environmental pollution and lifestyle changes have shifted focus to paternal sperm quality and its impact on offspring health before conception.Future studies should explore how different envi-ronmental and male infertility factors influence paternal epigenetics and how specific marks affect embryonic development,ulti-mately enhancing diagnostics,treatments,and preconception care.
