Analysis on value of 18F-FDG PET/CT in differential diagnosis for thymic epithelial tumors of different histological types
10.3969/j.issn.1672-8270.2025.11.010
- VernacularTitle:18F-FDG PET/CT在不同组织学分型胸腺上皮肿瘤中的鉴别诊断价值分析
- Author:
Yabing SUN
1
;
Xiaodan XU
1
;
Shuwei SUN
1
;
Jingbin SONG
1
;
Dong ZHAO
1
;
Guanyun WANG
1
;
Baixuan XU
1
;
Ruimin WANG
1
Author Information
1. 中国人民解放军总医院第一医学中心核医学科 北京 100853
- Publication Type:Journal Article
- Keywords:
Thymic epithelial tumor;
Metabolic parameters;
18F-fluorodeoxyglucose positron-emission tomography/computed tomography(18F-FDG PET/CT);
Differential diagnosis
- From:
China Medical Equipment
2025;22(11):65-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the differentially diagnostic ability of metabolic parameters of 18F-fluorodeoxyglucose positron-emission tomography/computed tomography(18F-FDG PET/CT)in thymic epithelial tumors(TETs)of different histological types.Methods:A total of 72 patients who underwent 18F-FDG PET/CT examination and were confirmed as TETs before treatment at the Department of Nuclear Medicine of the First Medical Center of Chinese PLA General Hospital between January 2013 to May 2022 were analyzed.The patients were divided into thymic tumor with low risk group(9 cases),thymic tumor with high risk group(15 cases)and thymic cancer group(9 cases)according to histological type.The clinical data of patients were recorded,and the patients were staged according to pathological Masaoka-Koga staging of thymic tumor surgery.The maximum standardized uptake value(SUVmax),average standardized uptake value(SUVmean),metabolic tumor volume(MTV),total lesion glycolysis(TLG)and standardized uptake value ratio(SUVR)of the lesions were recorded respectively.The differences of metabolic parameters of various group were compared.The area under curve(AUC)value of receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of 18F-FDG PET/CT in TETs of different histological types.Results:The results of analyzing each metabolic parameter of three groups indicated that the SUVmax,SUVmean and SUVR values of thymic tumor with high risk group and thymic cancer group were significantly higher than them of thymic tumor with low risk group,and the differences were significant(F=10.315,8.336,11.593,P<0.05),respectively.SUVR has the highest diagnostic efficacy in the differential diagnosis for thymic tumor and thymic cancer(AUC:0.864,sensitivity:83.3%,specificity:75.0%),and for thymic tumor with high-risk and thymic cancer(AUC:0.832,sensitivity:56.3%,specificity:100.0%).In addition,SUVR has the highest diagnostic efficacy for thymic tumor with high-risk and thymic tumor with low-risk(AUC:0.748,sensitivity:80.0%,specificity:66.7%).Conclusion:The metabolic parameters of 18F-FDG PET/CT have a certain of differential and diagnostic value in identifying TETs of different histological types.
