The effect of combined treatment with allergen barrier agent and AIT in patients with allergic rhinitis
10.3760/cma.j.cn101721-20241230-00455
- VernacularTitle:过敏原阻隔剂与AIT联合治疗变应性鼻炎患者的效果
- Author:
Wenhui MA
1
;
Yue ZHAO
1
Author Information
1. 大连医科大学附属第二医院耳鼻咽喉科，大连 116000
- Publication Type:Journal Article
- Keywords:
Allergic rhinitis;
Allergen blocker;
Dust mite mixture;
Allergen-specific immunotherapy
- From:
Clinical Medicine of China
2025;41(5):379-385
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore and analyze the clinical effect of allergen blocker, dust mite mixture sublingual allergen-specific immunotherapy (AIT) alone and in combination in the treatment of allergic rhinitis.Methods:The clinical data of 96 patients with allergic rhinitis in The Second Affiliated Hospital of Dalian Medical University from May 2022 to May 2024 were selected for prospective study. According to the principle of balanced and comparable baseline data between groups, they were divided into three groups by adopting random number table method, with 32 cases in each group. Patients in the conventional group were treated with allergen blocker, patients in the AIT group were given dust mite mixture sublingual therapy, and patients in the combined group received combined therapy with allergen blocker and dust mite mixture sublingual therapy. The clinical effects of three groups after treatment were observed, including symptoms scores, inflammatory indicators, immunoglobulins and adverse reactions. Enumeration data were expressed as case (%), and comparison among groups was performed by χ2 test. Measurement data with normal distribution was expressed as xˉ± s. One-way ANOVA was used for comparison among the three groups, and LSD- t test was used for pairwise comparison. Paired sample t-test was used for intra group comparison, and repeated measures data were analyzed using repeated measures ANOVA. Results:After treatment, the differences in the scores of nasal congestion, nasal itching, sneezing and runny nose among three groups of patients were statistically significant( P<0.05). The nasal congestion score was expressed as combined group
