Research progress on serrated polyposis syndrome
10.3760/cma.j.cn101721-20240910-00288
- VernacularTitle:锯齿状息肉病综合征的研究进展
- Author:
Jing QIAO
1
;
Ze WANG
1
;
Yinglong HUANG
1
Author Information
1. 内蒙古医科大学附属医院消化内科，呼和浩特 010050
- Publication Type:Journal Article
- Keywords:
Serrated polyposis syndrome;
Colorectal cancer;
Genetic basis
- From:
Clinical Medicine of China
2025;41(4):311-315
- CountryChina
- Language:Chinese
-
Abstract:
Serrated polyposis syndrome (SPS), characterized by multiple serrated polyps on the colorectum, is associated with a high risk of colorectal cancer. Serrated polyps eventually develop into colorectal cancer through a serrated pathway. In addition, the flat shape of serrated polyps and the mucus cap on the surface make them easy to miss the diagnosis under endoscopy, which is the main cause of intercolonic cancer. Therefore, the increased risk of colorectal cancer makes it necessary for patients with SPS to be accurately diagnosed, comprehensively managed, and appropriately treated and monitored. In recent years, the WHO has updated the diagnostic criteria and follow-up monitoring of SPS, and the research on the molecular genetic characteristics of SPS has also advanced.
