Research progress of transforming growth factor β-activated kinase 1 signaling pathway in inflammatory response and airway remodeling of COPD
10.3760/cma.j.cn101721-20250530-00235
- VernacularTitle:TAK1信号通路在COPD炎症反应及气道重塑中的研究进展
- Author:
Zhuqing CAI
1
;
Rong QIU
;
Yufang HUANG
Author Information
1. 遂宁市中心医院全科医学科，遂宁 629000
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Transforming growth factor β-activated kinase 1;
Signal pathway;
Inflammatory response;
Airway remodeling;
Targeted
- From:
Clinical Medicine of China
2025;41(6):476-480
- CountryChina
- Language:Chinese
-
Abstract:
Chronic Obstructive Pulmonary Disease (COPD) is a chronic airway inflammatory disorder characterized by persistent airflow limitation, involving complex inflammatory responses and airway structural remodeling in its pathophysiological process. Recent studies indicate that the Transforming Growth Factor-β-Activated Kinase 1 (TAK1) signaling pathway plays a pivotal regulatory role in the pathogenesis and progression of various pulmonary diseases. This review systematically summarizes the fundamental biological functions of the TAK1 signaling pathway, with a focus on its mechanistic involvement in inflammatory responses and airway remodeling in COPD. Additionally, we synthesize recent advances in targeted therapeutic strategies, including TAK1 inhibitors, and evaluate their potential clinical applications. This work aims to provide theoretical support and research direction for elucidating COPD pathogenesis and developing novel targeted therapies.
